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Anti-PyLT [PyC]


Catalogue Number 151188
Applications IF IP WB
Antigen/Gene or Protein Targets Polyoma virus Early antigens
Reactivity Virus
Relevance The mouse polyoma virus (Py) is an oncogenic virus, which encodes for three early proteins, large, middle and small T (tumour) antigen. PyC allows the detection and isolation of all three viral T antigens.
Host Rat
Immunogen Polyoma virus-transformed Wistar rat fibroblast cell line Py REWA5/T1A1.
Subclass IgG2b
Molecular Weight (kDa) 100/55/23
Myeloma Used P3/NS1/1-Ag4.1
Recommended Growing Conditions RPMI 1640 + 5% FCS
Notes Large T antigen: 100kDa, Middle T antigen: 55kDa, Small T antigen 23kDa. These antigens indicate a nuclear and cytoplasmic localisation in cells infected or transformed by polyoma virus.
Research Area Virology

References: 2 entries

Dilworth et al. 1982. EMBO J. 1(11):1319-28. PMID: 6327264.

Dilworth et al. 1982. Proc Natl Acad Sci U S A. 79(4):1059-63. PMID: 6175960.

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