Anti-Leu1 [UCH-T2]
Invented by Prof Peter Beverley from Imperial College
Invented at University College London
- Datasheet
- References (5)
- Inventor Info
Info
| Catalogue Number | 151176 |
| Applications | IHC IF WB |
| Antigen/Gene or Protein Targets | Leu1 (CD5) |
| Synonyms | CD5 Molecule 2; Lymphocyte Antigen T1/Leu-1; LEU1; CD5 Antigen; T1 |
| Reactivity | Human |
| Relevance | Leu-1 is a surface glycoprotein present on peripheral T cells (>95%) and B-cell chronic lymphocytic leukaemia cells that binds CD72. Absence of the Leu-1 marker on childhood ALL cells is associated with a more favourable prognosis. UCH-T2 is useful for detection of T cells in peripheral blood and lymph nodes and categorisation of T cell lymphomas and B cell chronic lymphocytic leukaemia. |
| Host | Mouse |
| Immunogen | Thymocytes followed by Sezary T cells. |
| Subclass | IgG1 kappa |
| Recommended Growing Conditions | RPMI + 7.5% FCS |
| Strain | Balb/c |
| Notes | Recommended for Immunofluorescence and immunostaining of frozen samples and the enrichment of T cell populations by cell sorting or panning. |
| Research Area | Immunology, Stem Cell Biology |
References: 5 entries
Beverley PE & Callard RE. 1982. Protides Biol. Fluids. Colloq. 29:653-8.
Kap et al. 2009. J Histochem Cytochem. 57(12):1159-67. PMID: 19729671.
A monoclonal antibody selection for immunohistochemical examination of lymphoid tissues from non-human primates.
Europe PMC ID: 19729671
Gary-Gouy et al. 2007. J Immunol. 179(7):4335-44. PMID: 17878328.
Natural phosphorylation of CD5 in chronic lymphocytic leukemia B cells and analysis of CD5-regulated genes in a B cell line suggest a role for CD5 in malignant phenotype.
Europe PMC ID: 17878328
Add a reference
References: 5 entries
Beverley PE & Callard RE. 1982. Protides Biol. Fluids. Colloq. 29:653-8.
Kap et al. 2009. J Histochem Cytochem. 57(12):1159-67. PMID: 19729671.
A monoclonal antibody selection for immunohistochemical examination of lymphoid tissues from non-human primates.
Gary-Gouy et al. 2007. J Immunol. 179(7):4335-44. PMID: 17878328.
Natural phosphorylation of CD5 in chronic lymphocytic leukemia B cells and analysis of CD5-regulated genes in a B cell line suggest a role for CD5 in malignant phenotype.
Add a reference
