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|Applications||FACS IHC IP WB|
|Antigen/Gene or Protein Targets||Protein tyrosine phosphatase, receptor type, C (PTPRC, CD45RO)|
|Synonyms||Protein Tyrosine Phosphatase; Receptor Type C; CD45 Antigen; CD45; L-CA; T200; Protein Tyrosine Phosphatase; Receptor Type; C Polypeptide; T200 Leukocyte Common Antigen; T200 Glycoprotein; EC 188.8.131.52; GP180; CD45R; B220; LCA; LY5|
|Relevance||PTPRC (CD45) is a transmembrane tyrosine phosphatase that is present on all leukocytes. PTPRC regulates the threshold of T cell antigen receptor (TCR) signaling through dephosphorylation of protein tyrosine kinases (e.g. Lck and Fyn). CD45R and CD45RO are two of multiple PTPRC isoforms generated by alternative splicing. CD45R is found on B lymphocyte and T lymphocyte subsets. CD45RO is present on 50% of T cells, most granulocytes and monocytes and most mature T cell tumours. This antibody reacts with an epitope unique for CD45R0. It may identify abnormalities of functional T-cell subsets in immune disorders, be used in tumour diagnosis by FACS or immunohistology and has been very useful in studies of human T cell function and ontogeny.|
|Immunogen||Cultured T cells from an IL-2-dependent T-cell line (CA1) prepared from human peripheral blood activated with influenza virus.|
|Molecular Weight (kDa)||180|
|Recommended Growing Conditions||RPMI + 10% FCS.|
|Research Area||Cancer, Cell Type or Organelle Marker, Epitope Tags, Immunology|
References: 5 entries
Zlobec et al. 2013. J Transl Med. 11:104. PMID: 23627766.
Dornan et al. 2002. J Biol Chem. 277(3):1912-8. PMID: 11694532.
Ishii et al. 2001. Proc Natl Acad Sci U S A. 98(21):12138-43. PMID: 11593028.
Ponsford et al. 2001. Clin Exp Immunol. 124(2):315-22. PMID: 11422210.
Smith et al. 1986. Immunology. 58(1):63-70. PMID: 2423439.
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