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Anti-CD45RO [UCH-L1]


Catalogue Number 151173
Applications FACS IHC IP WB
Antigen/Gene or Protein Targets Protein tyrosine phosphatase, receptor type, C (PTPRC, CD45RO)
Synonyms Protein Tyrosine Phosphatase; Receptor Type C; CD45 Antigen; CD45; L-CA; T200; Protein Tyrosine Phosphatase; Receptor Type; C Polypeptide; T200 Leukocyte Common Antigen; T200 Glycoprotein; EC; GP180; CD45R; B220; LCA; LY5
Reactivity Human
Relevance PTPRC (CD45) is a transmembrane tyrosine phosphatase that is present on all leukocytes. PTPRC regulates the threshold of T cell antigen receptor (TCR) signaling through dephosphorylation of protein tyrosine kinases (e.g. Lck and Fyn). CD45R and CD45RO are two of multiple PTPRC isoforms generated by alternative splicing. CD45R is found on B lymphocyte and T lymphocyte subsets. CD45RO is present on 50% of T cells, most granulocytes and monocytes and most mature T cell tumours. This antibody reacts with an epitope unique for CD45R0. It may identify abnormalities of functional T-cell subsets in immune disorders, be used in tumour diagnosis by FACS or immunohistology and has been very useful in studies of human T cell function and ontogeny.
Host Mouse
Immunogen Cultured T cells from an IL-2-dependent T-cell line (CA1) prepared from human peripheral blood activated with influenza virus.
Subclass IgG2a
Molecular Weight (kDa) 180
Myeloma Used P3/NS1/1-Ag4.1
Recommended Growing Conditions RPMI + 10% FCS.
Strain Balb/c
Research Area Cancer, Cell Type or Organelle Marker, Epitope Tags, Immunology

References: 5 entries

Zlobec et al. 2013. J Transl Med. 11:104. PMID: 23627766.

Dornan et al. 2002. J Biol Chem. 277(3):1912-8. PMID: 11694532.

Ishii et al. 2001. Proc Natl Acad Sci U S A. 98(21):12138-43. PMID: 11593028.

Ponsford et al. 2001. Clin Exp Immunol. 124(2):315-22. PMID: 11422210.

Smith et al. 1986. Immunology. 58(1):63-70. PMID: 2423439.

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