Anti-Fibrin [UC45]
Invented by Prof Nancy Hogg from Cancer Research UK London Research Institute: Lincoln's Inn Fields
Invented at Cancer Research UK London Research Institute: Lincoln's Inn Fields
- Datasheet
- References (8)
- Inventor Info
Info
| Catalogue Number | 151172 |
| Applications | FACS IF IP RIA |
| Antigen/Gene or Protein Targets | Fibrin alpha chain |
| Reactivity | Human |
| Relevance | Fibrin (also called Factor Ia) is a fibrous protein involved in the clotting of blood, and is non-globular. It is a fibrillar protein that is polymerised to form a "mesh" that forms a hemostatic plug or clot (in conjunction with platelets) over a wound site. |
| Host | Mouse |
| Immunogen | Human acute monoblastic leukemia cells. |
| Subclass | IgM |
| Molecular Weight (kDa) | 45 |
| Myeloma Used | P3/NS1/1-Ag4.1 |
| Recommended Growing Conditions | DMEM + 5% FCS |
| Strain | Balb/c |
| Notes | UC45 is specific for monocytic leukemias. The relevant antigens are not expressed in all cases with monocytic differentiation. Cross reacts with fibrinogen. |
| Research Area | Cardiovascular |
References: 8 entries
Wu et al. 2013. Am J Nucl Med Mol Imaging. 3(5):446-55. PMID: 24116353.
Molecular MRI of atherosclerotic plaque progression in an ApoE(-/-) mouse model with a CLT1 peptide targeted macrocyclic Gd(III) chelate.
Europe PMC ID: 24116353
Linch et al. 1984. Blood. 63(3):566-73. PMID: 6365201.
Monoclonal antibodies differentiating between monocytic and nonmonocytic variants of AML.
Europe PMC ID: 6365201
Hogg et al. 1983. J Exp Med. 157(2):473-85. PMID: 6822786.
IF
Human monocytes are associated with the formation of fibrin.
Europe PMC ID: 6822786
Hogg et al. 1981. Cell. 24(3):875-84. PMID: 6788378.
Monoclonal antibody with specificity for monocytes and neurons.
Europe PMC ID: 6788378
Add a reference
References: 8 entries
Wu et al. 2013. Am J Nucl Med Mol Imaging. 3(5):446-55. PMID: 24116353.
Molecular MRI of atherosclerotic plaque progression in an ApoE(-/-) mouse model with a CLT1 peptide targeted macrocyclic Gd(III) chelate.
Linch et al. 1984. Blood. 63(3):566-73. PMID: 6365201.
Monoclonal antibodies differentiating between monocytic and nonmonocytic variants of AML.
Hogg et al. 1983. J Exp Med. 157(2):473-85. PMID: 6822786.
IF
Human monocytes are associated with the formation of fibrin.
Hogg et al. 1981. Cell. 24(3):875-84. PMID: 6788378.
Monoclonal antibody with specificity for monocytes and neurons.
Add a reference
