Anti-LewisX [TG-1]
Invented by Prof Peter Beverley from Imperial College
Invented at Cancer Research UK London Research Institute: Lincoln's Inn Fields
- Datasheet
- References (8)
- Inventor Info
Info
| Catalogue Number | 151165 |
| Applications | FACS IHC IF |
| Antigen/Gene or Protein Targets | Lewis X (CD15) |
| Synonyms | Fucosyltransferase 4; Galactoside 3-L-Fucosyltransferase; ELAM-1 Ligand Fucosyltransferase; FUC-TIV; FCT3A; ELFT; Stage-Specific Embryonic Antigen; Alpha (1,3) Fucosyltransferase; EC 2.4.1.65; Lewis X; SSEA-1; FUTIV; CD15; LeX |
| Reactivity | Human |
| Relevance | Lewis X (CD15) is a branched pentasaccharide found on neutrophils, eosinophils and monocytes. Lewis X is distributed abnormally in myeloid leukeamias and is commonly used in the diagnosis of Hodgkin’s disease. TG-1 is useful for the differentiation of human leukocytes. |
| Host | Mouse |
| Immunogen | Thymocyte glycoprotein fraction adsorbed to Con A and eluted with 0.1M glucose. |
| Subclass | IgM |
| Molecular Weight (kDa) | 156 |
| Myeloma Used | P3/NS1/1-Ag4.1 |
| Recommended Growing Conditions | DMEM + 5% FCS |
| Strain | CBA |
| Notes | TG-1 is cytotoxic with rabbit complement. |
| Research Area | Cancer, Immunology |
References: 8 entries
Cho et al. 2010. J Proteome Res. 9(11):5960-8. PMID: 20858014.
FACS
Sialylated Lewis x antigen bearing glycoproteins in human plasma.
Europe PMC ID: 20858014
Hogg et al. 1984. Immunology. 53(4):753-67. PMID: 6389324.
Monoclonal antibodies specific for human monocytes, granulocytes and endothelium.
Europe PMC ID: 6389324
Linch et al. 1984. Blood. 63(3):566-73. PMID: 6365201.
Monoclonal antibodies differentiating between monocytic and nonmonocytic variants of AML.
Europe PMC ID: 6365201
Beverley et al. 1980. Nature. 287(5780):332-3. PMID: 7421991.
Isolation of human haematopoietic progenitor cells using monoclonal antibodies.
Europe PMC ID: 7421991
Add a reference
References: 8 entries
Cho et al. 2010. J Proteome Res. 9(11):5960-8. PMID: 20858014.
FACS
Sialylated Lewis x antigen bearing glycoproteins in human plasma.
Hogg et al. 1984. Immunology. 53(4):753-67. PMID: 6389324.
Monoclonal antibodies specific for human monocytes, granulocytes and endothelium.
Linch et al. 1984. Blood. 63(3):566-73. PMID: 6365201.
Monoclonal antibodies differentiating between monocytic and nonmonocytic variants of AML.
Beverley et al. 1980. Nature. 287(5780):332-3. PMID: 7421991.
Isolation of human haematopoietic progenitor cells using monoclonal antibodies.
Add a reference
