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Anti-CD4 V1 domain [QS4120]

Invented by Prof Peter Beverley at Imperial College

Info

Catalogue Number 151155
Applications ELISA FACS IF Fn
Antigen/Gene or Protein Targets CD4 V1 domain
Synonyms CD4 Molecule; T-Cell Surface Antigen T4/Leu-3; T-Cell Surface Glycoprotein CD4; CD4 Receptor; CD4 Antigen
Reactivity Human
Relevance CD4 is a T cell co-receptor that recognises, together with the T cell receptor, MHC class II molecules. CD4 cell counts are used as indicator of AIDS progression. In addition to virus binding, CD4 may have an active role in membrane fusion.

Anti-CD4 V1 domain [QS4120] binds to domain 1 of CD4 and blocks binding of gp120 to CD4 (Ringe and Bhattacharya, 2012).
Host Mouse
Immunogen CD4+ transfectant followed by CEM cells
Subclass IgG1
Recommended Growing Conditions DMEM + 5% FCS
Notes QS4120 inhibits HIV sycytium function in cocultivation assays.
Research Area Immunology, Stem Cell Biology

References: 14 entries

Helling et al. 2015. Immunol Cell Biol. 93(4):396-405. PMID: 25512343.

A specific CD4 epitope bound by tregalizumab mediates activation of regulatory T cells by a unique signaling pathway.

Europe PMC ID: 25512343

Ringe et al. 2012. PLoS One. 7(5):e37157. PMID: 22606344.

Fn

Association of enhanced HIV-1 neutralization by a single Y681H substitution in gp41 with increased gp120-CD4 interaction and macrophage infectivity.

Europe PMC ID: 22606344

Sadovnikova et al. 2002. Leukemia. 16(10):2019-26. PMID: 12357353.

The CD68 protein as a potential target for leukaemia-reactive CTL.

Europe PMC ID: 12357353

Dornan et al. 2002. J Biol Chem. 277(3):1912-8. PMID: 11694532.

Differential association of CD45 isoforms with CD4 and CD8 regulates the actions of specific pools of p56lck tyrosine kinase in T cell antigen receptor signal transduction.

Europe PMC ID: 11694532

Ugolini et al. 1997. J Immunol. 159(6):3000-8. PMID: 9300725.

HIV-1 gp120 induces an association between CD4 and the chemokine receptor CXCR4.

Europe PMC ID: 9300725

Healey et al. 1990. J Exp Med. 172(4):1233-42. PMID: 1698911.

Novel anti-CD4 monoclonal antibodies separate human immunodeficiency virus infection and fusion of CD4+ cells from virus binding.

Europe PMC ID: 1698911

McClure et al. 1987. Nature. 330(6147):487-9. PMID: 2446142.

HIV infection of primate lymphocytes and conservation of the CD4 receptor.

Europe PMC ID: 2446142


Add a reference

References: 14 entries

Helling et al. 2015. Immunol Cell Biol. 93(4):396-405. PMID: 25512343.

A specific CD4 epitope bound by tregalizumab mediates activation of regulatory T cells by a unique signaling pathway.

Europe PMC ID: 25512343

Ringe et al. 2012. PLoS One. 7(5):e37157. PMID: 22606344.

Fn

Association of enhanced HIV-1 neutralization by a single Y681H substitution in gp41 with increased gp120-CD4 interaction and macrophage infectivity.

Europe PMC ID: 22606344

Sadovnikova et al. 2002. Leukemia. 16(10):2019-26. PMID: 12357353.

The CD68 protein as a potential target for leukaemia-reactive CTL.

Europe PMC ID: 12357353

Dornan et al. 2002. J Biol Chem. 277(3):1912-8. PMID: 11694532.

Differential association of CD45 isoforms with CD4 and CD8 regulates the actions of specific pools of p56lck tyrosine kinase in T cell antigen receptor signal transduction.

Europe PMC ID: 11694532

Ugolini et al. 1997. J Immunol. 159(6):3000-8. PMID: 9300725.

HIV-1 gp120 induces an association between CD4 and the chemokine receptor CXCR4.

Europe PMC ID: 9300725

Healey et al. 1990. J Exp Med. 172(4):1233-42. PMID: 1698911.

Novel anti-CD4 monoclonal antibodies separate human immunodeficiency virus infection and fusion of CD4+ cells from virus binding.

Europe PMC ID: 1698911

McClure et al. 1987. Nature. 330(6147):487-9. PMID: 2446142.

HIV infection of primate lymphocytes and conservation of the CD4 receptor.

Europe PMC ID: 2446142


Add a reference

References: 14 entries

Helling et al. 2015. Immunol Cell Biol. 93(4):396-405. PMID: 25512343.

A specific CD4 epitope bound by tregalizumab mediates activation of regulatory T cells by a unique signaling pathway.

Ringe et al. 2012. PLoS One. 7(5):e37157. PMID: 22606344.

Fn

Association of enhanced HIV-1 neutralization by a single Y681H substitution in gp41 with increased gp120-CD4 interaction and macrophage infectivity.

Sadovnikova et al. 2002. Leukemia. 16(10):2019-26. PMID: 12357353.

The CD68 protein as a potential target for leukaemia-reactive CTL.

Dornan et al. 2002. J Biol Chem. 277(3):1912-8. PMID: 11694532.

Differential association of CD45 isoforms with CD4 and CD8 regulates the actions of specific pools of p56lck tyrosine kinase in T cell antigen receptor signal transduction.

Ugolini et al. 1997. J Immunol. 159(6):3000-8. PMID: 9300725.

HIV-1 gp120 induces an association between CD4 and the chemokine receptor CXCR4.

Healey et al. 1990. J Exp Med. 172(4):1233-42. PMID: 1698911.

Novel anti-CD4 monoclonal antibodies separate human immunodeficiency virus infection and fusion of CD4+ cells from virus binding.

McClure et al. 1987. Nature. 330(6147):487-9. PMID: 2446142.

HIV infection of primate lymphocytes and conservation of the CD4 receptor.


Add a reference


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