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Anti-PCNA [PC8]


Catalogue Number 151151
Applications IHC IP WB
Antigen/Gene or Protein Targets Proliferating cell nuclear antigen, (PCNA), also known as cyclin or polymerase delta accessory protein
Synonyms Proliferating Cell Nuclear Antigen; DNA Polymerase Delta Auxiliary Protein; ATLD2
Reactivity Human, Schizosaccharomyces pombe and Saccharomyces frugiperda
Relevance PCNA, also known as polymerase delta auxiliary protein, is essential for DNA replication and is involved in DNA excision and mismatch repair pathways. PCNA binds to the CDK inhibitor p21, the structure-specific endonucleases Fen1 and XPG, and DNA cytosine 5-methyltransferase (MCMT). PCNA is a potentially useful marker of cells with proliferative potential and for identifying the proliferation status of tumour tissue (i.e. relevant to prognosis).
Host Mouse
Immunogen Protein A-PCNA fusion obtained from pC2T.
Subclass IgG3
Myeloma Used Sp2/0-Ag14
Recommended Growing Conditions RPMI 1640 + 5% FCS.
Notes The PCNA Epitope also found in Schizosaccharomyces pombe (yeast) and Spodoptera frugiperda (insect) in addition to man. PC8 is recommended for use on formalin-fixed paraffin embedded sections.
Research Area Cancer, Cell Cycle, Cell Type or Organelle Marker, Epigenetics & Nuclear Signalling

References: 2 entries

Yu et al. 1995. Anal Cell Pathol. 9(1):45-52. PMID: 7577754.


Waseem et al. 1990. J Cell Sci. 96 ( Pt 1):121-9. PMID: 1695635.

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