Anti-p53 [Pab 1802]
Invented by Dr Lawrence Banks from International Centre For Genetic Engineering And Biotechnology (ICGEB)
Invented at Cancer Research UK London Research Institute: Lincoln's Inn Fields
- Datasheet
- References (2)
- Inventor Info
Info
| Catalogue Number | 151145 |
| Applications | ELISA IHC IP WB |
| Antigen/Gene or Protein Targets | p53 |
| Synonyms | Tumor Protein P53; Phosphoprotein P53; Antigen NY-CO-13; P53; Transformation-Related Protein 53; Mutant Tumor Protein 53; Li-Fraumeni Syndrome; P53 Tumor Suppressor; Tumor Suppressor P53; TRP53; BCC7; LFS1 |
| Reactivity | Human and Mouse |
| Relevance | p53 is a stress-regulated transcription factor that regulates cell cycle arrest and was first identified as an SV40 large T antigen-binding protein. Mutation of p53 is the most common genetic change so far identified in a number of major carcinomas. PAB 1802 may be used to show the expression of human p53 cDNA in cos-l cells. |
| Host | Mouse |
| Immunogen | P53-beta galactosidase fusion protein |
| Positive Control | MDA-MB-231 cell line |
| Subclass | IgG1 |
| Molecular Weight (kDa) | 53 |
| Myeloma Used | P3/NS1/1-Ag4.1 |
| Recommended Growing Conditions | DMEM + 5% FCS |
| Notes | PAB 1802 cross reacts with the murine epitope in C-terminal region between residues 306-393 in both wild type & mutant forms. |
| Research Area | Apoptosis and Programmed Cell Death, Cancer, Cell Cycle, DNA Damage and Repair, Epigenetics & Nuclear Signalling |
References: 2 entries
Banks et al. 1986. Eur J Biochem. 159(3):529-34. PMID: 2428616.
Isolation of human-p53-specific monoclonal antibodies and their use in the studies of human p53 expression.
Europe PMC ID: 2428616
Add a reference
References: 2 entries
Banks et al. 1986. Eur J Biochem. 159(3):529-34. PMID: 2428616.
Isolation of human-p53-specific monoclonal antibodies and their use in the studies of human p53 expression.
Add a reference
