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Anti-p53 [Pab 1802]


Catalogue Number 151145
Applications ELISA IHC IP WB
Antigen/Gene or Protein Targets p53
Synonyms Tumor Protein P53; Phosphoprotein P53; Antigen NY-CO-13; P53; Transformation-Related Protein 53; Mutant Tumor Protein 53; Li-Fraumeni Syndrome; P53 Tumor Suppressor; Tumor Suppressor P53; TRP53; BCC7; LFS1
Reactivity Human and Mouse
Relevance p53 is a stress-regulated transcription factor that regulates cell cycle arrest and was first identified as an SV40 large T antigen-binding protein. Mutation of p53 is the most common genetic change so far identified in a number of major carcinomas. PAB 1802 may be used to show the expression of human p53 cDNA in cos-l cells.
Host Mouse
Immunogen P53-beta galactosidase fusion protein
Subclass IgG1
Positive Control MDA-MB-231 cell line
Molecular Weight (kDa) 53
Myeloma Used P3/NS1/1-Ag4.1
Recommended Growing Conditions DMEM + 5% FCS
Notes PAB 1802 cross reacts with the murine epitope in C-terminal region between residues 306-393 in both wild type & mutant forms.
Research Area Apoptosis and Programmed Cell Death, Cancer, Cell Cycle, DNA Damage and Repair, Epigenetics & Nuclear Signalling

References: 1 entry

Banks et al. 1986. Eur J Biochem. 159(3):529-34. PMID: 2428616.

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