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Anti-p53 [Pab 1104]


Catalogue Number 151143
Applications IHC IP
Antigen/Gene or Protein Targets p53
Reactivity Human
Relevance PAb1104 has distinct, intrinsic activities towards both p53 and SV40 large T-antigen. Only a subset of T-antigen is bound by PAb1104.
Host Mouse
Immunogen A slice of gel containing p53 homogenised in PBS. The p53 was extracted from the human SV40-transformed fibroblast cell line SV80 and purified by immunoprecipitation and SDS gel electrophoresis.
Subclass IgM
Positive Control MDA-MB-231 cell line
Myeloma Used P3/NS1/1-Ag4.1
Recommended Growing Conditions RPMI 1640 + 5% FCS
Strain Balb/c
Notes Reacts with human p53 and an oligomeric form of SV60 large T antigen
Research Area Apoptosis and Programmed Cell Death, Cancer, Cell Cycle, DNA Damage and Repair, Epigenetics & Nuclear Signalling

References: 3 entries

Nayak et al. 2007. Cancer Res. 67(12):5831-9. PMID: 17575151.

Leppard et al. 1984. J Virol. 50(2):457-64. PMID: 6323746.

Leppard et al. 1983. EMBO J. 2(9):1457-64. PMID: 11892796.

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