Anti-p53 [Pab 1104]
Invented at Cancer Research UK London Research Institute: Lincoln's Inn Fields
- Datasheet
- References (6)
- Inventor Info
Info
| Catalogue Number | 151143 |
| Applications | IHC IP |
| Antigen/Gene or Protein Targets | p53 |
| Reactivity | Human |
| Relevance | PAb1104 has distinct, intrinsic activities towards both p53 and SV40 large T-antigen. Only a subset of T-antigen is bound by PAb1104. |
| Host | Mouse |
| Immunogen | A slice of gel containing p53 homogenised in PBS. The p53 was extracted from the human SV40-transformed fibroblast cell line SV80 and purified by immunoprecipitation and SDS gel electrophoresis. |
| Positive Control | MDA-MB-231 cell line |
| Subclass | IgM |
| Myeloma Used | P3/NS1/1-Ag4.1 |
| Recommended Growing Conditions | RPMI 1640 + 5% FCS |
| Strain | Balb/c |
| Notes | Reacts with human p53 and an oligomeric form of SV60 large T antigen |
| Research Area | Apoptosis and Programmed Cell Death, Cancer, Cell Cycle, DNA Damage and Repair, Epigenetics & Nuclear Signalling |
References: 6 entries
Nayak et al. 2007. Cancer Res. 67(12):5831-9. PMID: 17575151.
Effect of a single nucleotide polymorphism in the murine double minute 2 promoter (SNP309) on the sensitivity to topoisomerase II-targeting drugs.
Europe PMC ID: 17575151
Leppard et al. 1984. J Virol. 50(2):457-64. PMID: 6323746.
An oligomeric form of simian virus 40 large T-antigen is immunologically related to the cellular tumor antigen p53.
Europe PMC ID: 6323746
Leppard et al. 1983. EMBO J. 2(9):1457-64. PMID: 11892796.
Monoclonal antibodies displaying a novel species specificity for the primate transformation-related protein, p53.
Europe PMC ID: 11892796
Add a reference
References: 6 entries
Nayak et al. 2007. Cancer Res. 67(12):5831-9. PMID: 17575151.
Effect of a single nucleotide polymorphism in the murine double minute 2 promoter (SNP309) on the sensitivity to topoisomerase II-targeting drugs.
Leppard et al. 1984. J Virol. 50(2):457-64. PMID: 6323746.
An oligomeric form of simian virus 40 large T-antigen is immunologically related to the cellular tumor antigen p53.
Leppard et al. 1983. EMBO J. 2(9):1457-64. PMID: 11892796.
Monoclonal antibodies displaying a novel species specificity for the primate transformation-related protein, p53.
Add a reference
