Anti-p53 [Pab 1103]
Invented at Cancer Research UK London Research Institute: Lincoln's Inn Fields
- Datasheet
- References (4)
- Inventor Info
Info
| Catalogue Number | 151142 |
| Applications | IHC IP WB |
| Antigen/Gene or Protein Targets | p53. large T-associated form of p53. |
| Reactivity | Human |
| Relevance | p53 is a stress-regulated transcription factor that regulates cell cycle arrest and was first identified as an SV40 large T antigen-binding protein. Mutation of p53 is the most common genetic change so far identified in a number of major carcinomas. Pab 1103 is useful as research reagent to investigate structural similarity between large T and p53. |
| Host | Mouse |
| Immunogen | A slice of gel containing p53 homogenised in PBS. The p53 was extracted from the human SV40-transformed fibroblast cell line SV80 and purified by immunoprecipitation and SDS gel electrophoresis. |
| Positive Control | MDA-MB-231 cell line |
| Subclass | IgM |
| Molecular Weight (kDa) | 53 |
| Recommended Growing Conditions | DMEM + 5% FCS |
| Strain | Balb/c |
| Research Area | Apoptosis and Programmed Cell Death, Cancer, Cell Cycle, DNA Damage and Repair, Epigenetics & Nuclear Signalling |
References: 4 entries
Leppard et al. 1984. J Virol. 50(2):457-64. PMID: 6323746.
An oligomeric form of simian virus 40 large T-antigen is immunologically related to the cellular tumor antigen p53.
Europe PMC ID: 6323746
Leppard et al. 1983. EMBO J. 2(9):1457-64. PMID: 11892796.
Monoclonal antibodies displaying a novel species specificity for the primate transformation-related protein, p53.
Europe PMC ID: 11892796
Add a reference
References: 4 entries
Leppard et al. 1984. J Virol. 50(2):457-64. PMID: 6323746.
An oligomeric form of simian virus 40 large T-antigen is immunologically related to the cellular tumor antigen p53.
Leppard et al. 1983. EMBO J. 2(9):1457-64. PMID: 11892796.
Monoclonal antibodies displaying a novel species specificity for the primate transformation-related protein, p53.
Add a reference
