Log in Register

Anti-Integrin aV [P2W7]


Catalogue Number 151140
Applications FACS IHC IF IP WB
Antigen/Gene or Protein Targets Integrin alpha V (CD51)
Reactivity Human
Relevance Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin aV associates with integrin b3 to form the osteoclast functional antigen (vitronectin receptor). Integrin aV is found in osteoclasts, placenta, melanoma cell lines and some epithelial cell lines. Expression of integrin aV increases with melanoma progression.
Host Mouse
Immunogen Ocular melanoma cell line (V+B2) a clone expressing high levels of alpha-v, beta-1
Subclass IgG1
Positive Control A375M melanoma
Molecular Weight (kDa) 150-160
Recommended Growing Conditions DMEM + 5% FCS
Notes Human alpha v is about 150-160kDa under non-reducing conditions. Under reducing conditions it is cleaved into 2 bands of about 125-130kDa +20-25kDa.
Research Area Stem Cell Biology

References: 3 entries

Richards et al. 2011. J Virol. 85(17):8766-76. PMID: 21715474.

Misselwitz et al. 2011. Mol Syst Biol. 7:474. PMID: 21407211.

von Schlippe et al. 2000. J Cell Sci. 113 ( Pt 3):425-37. PMID: 10639330.

Add a reference

This reagent does not have any reviews at the moment.