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Anti-Integrin aV [P2W7]

Info

Catalogue Number 151140
Applications FACS IHC IF IP WB
Antigen/Gene or Protein Targets Integrin alpha V (CD51)
Reactivity Human
Relevance Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin aV associates with integrin b3 to form the osteoclast functional antigen (vitronectin receptor). Integrin aV is found in osteoclasts, placenta, melanoma cell lines and some epithelial cell lines. Expression of integrin aV increases with melanoma progression.
Host Mouse
Immunogen Ocular melanoma cell line (V+B2) a clone expressing high levels of alpha-v, beta-1
Subclass IgG1
Positive Control A375M melanoma
Molecular Weight (kDa) 150-160
Recommended Growing Conditions DMEM + 5% FCS
Notes Human alpha v is about 150-160kDa under non-reducing conditions. Under reducing conditions it is cleaved into 2 bands of about 125-130kDa +20-25kDa.
Research Area Stem Cell Biology

References: 8 entries

Murase et al. 2017. J Neurosci Res. :. PMID: 28509387.

IF WB

Progranulin increases phagocytosis by retinal pigment epithelial cells in culture.

Europe PMC ID: 28509387

Richards et al. 2011. J Virol. 85(17):8766-76. PMID: 21715474.

The cytoplasmic domain of rhesus cytomegalovirus Rh178 interrupts translation of major histocompatibility class I leader peptide-containing proteins prior to translocation.

Europe PMC ID: 21715474

Misselwitz et al. 2011. Mol Syst Biol. 7:474. PMID: 21407211.

RNAi screen of Salmonella invasion shows role of COPI in membrane targeting of cholesterol and Cdc42.

Europe PMC ID: 21407211

von Schlippe et al. 2000. J Cell Sci. 113 ( Pt 3):425-37. PMID: 10639330.

Functional interaction between E-cadherin and alphav-containing integrins in carcinoma cells.

Europe PMC ID: 10639330


Add a reference

References: 8 entries

Murase et al. 2017. J Neurosci Res. :. PMID: 28509387.

IF WB

Progranulin increases phagocytosis by retinal pigment epithelial cells in culture.

Europe PMC ID: 28509387

Richards et al. 2011. J Virol. 85(17):8766-76. PMID: 21715474.

The cytoplasmic domain of rhesus cytomegalovirus Rh178 interrupts translation of major histocompatibility class I leader peptide-containing proteins prior to translocation.

Europe PMC ID: 21715474

Misselwitz et al. 2011. Mol Syst Biol. 7:474. PMID: 21407211.

RNAi screen of Salmonella invasion shows role of COPI in membrane targeting of cholesterol and Cdc42.

Europe PMC ID: 21407211

von Schlippe et al. 2000. J Cell Sci. 113 ( Pt 3):425-37. PMID: 10639330.

Functional interaction between E-cadherin and alphav-containing integrins in carcinoma cells.

Europe PMC ID: 10639330


Add a reference

References: 8 entries

Murase et al. 2017. J Neurosci Res. :. PMID: 28509387.

IF WB

Progranulin increases phagocytosis by retinal pigment epithelial cells in culture.

Richards et al. 2011. J Virol. 85(17):8766-76. PMID: 21715474.

The cytoplasmic domain of rhesus cytomegalovirus Rh178 interrupts translation of major histocompatibility class I leader peptide-containing proteins prior to translocation.

Misselwitz et al. 2011. Mol Syst Biol. 7:474. PMID: 21407211.

RNAi screen of Salmonella invasion shows role of COPI in membrane targeting of cholesterol and Cdc42.

von Schlippe et al. 2000. J Cell Sci. 113 ( Pt 3):425-37. PMID: 10639330.

Functional interaction between E-cadherin and alphav-containing integrins in carcinoma cells.


Add a reference


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