Anti-Integrin alpha 2b + beta 3 [P256]
Invented by Prof Nancy Hogg from Cancer Research UK London Research Institute: Lincoln's Inn Fields
Invented at Imperial College
- Datasheet
- References (4)
- Inventor Info
Info
| Catalogue Number | 151138 |
| Applications | IHC IF IP WB |
| Antigen/Gene or Protein Targets | Integrin a2bß3 (CD41 & CD61) |
| Synonyms | alpha 2B/beta3, alphaIIbetabeta3, GPIIbetabeta3, CD41/CD61, platelet fibronectin receptor |
| Reactivity | Human |
| Relevance | Integrins are heterodimeric cell surface receptors composed of a and ß subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin a2b (CD41) and integrin ß3 (CD61) associate to form the heterodimer integrin a2bb3 (CD41/CD61; GPIIb/IIIa), a fibronectin receptor expressed in platelets. P256 has potential use for imaging of thrombi. P256 induces aggregation of normal platelets in plasma. |
| Host | Mouse |
| Immunogen | Peripheral blood mononuclear cells |
| Subclass | IgG1 |
| Molecular Weight (kDa) | 135 |
| Myeloma Used | P3/NS1/1-Ag4.1 |
| Recommended Growing Conditions | DMEM + 5% FCS |
| Strain | Balb/c |
| Research Area | Cancer |
References: 4 entries
Activation of platelets induced by mAb P256 specific for glycoprotein IIb-IIIa. Possible evidence for a role for IIb-IIIa in membrane signal transduction.
Europe PMC ID: 2364945
1989. Ann. Meeting Br. Nuclear Med. Soc. Abstracts. 243.
In vivo studies with an anti-platelet monoclonal antibody; P256.
Europe PMC ID: 3211440
Monoclonal antibodies specific for platelet glycoproteins react with human monocytes.
Europe PMC ID: 6234033
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References: 4 entries
Activation of platelets induced by mAb P256 specific for glycoprotein IIb-IIIa. Possible evidence for a role for IIb-IIIa in membrane signal transduction.
1989. Ann. Meeting Br. Nuclear Med. Soc. Abstracts. 243.
In vivo studies with an anti-platelet monoclonal antibody; P256.
Monoclonal antibodies specific for platelet glycoproteins react with human monocytes.
Add a reference
