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Anti-Integrin a2bb3 [P256]
RECENTLY UPDATED

Invented by Prof Nancy Hogg at Cancer Research UK London Research Institute: Lincoln's Inn Fields

Info

Catalogue Number 151138
Applications IHC IF IP WB
Antigen/Gene or Protein Targets Integrin a2bß3 (CD41 & CD61)
Synonyms Integrin Subunit Alpha 2; Alpha 2 Subunit Of VLA-2 Receptor; Platelet Membrane Glycoprotein Ia; CD49 Antigen-Like Family Member B; Collagen Receptor; CD49B; GPIa; Very Late Activation Protein 2 Receptor, Alpha-2 Subunit; Human Platelet Alloantigen System 5; Platelet Glycoprotein GPIa; Platelet Antigen Br; VLA-2 Subunit Alpha; CD49b Antigen; HPA-5; VLA-2; VLAA2; BR
Reactivity Human
Relevance Integrins are heterodimeric cell surface receptors composed of a and ß subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin a2b (CD41) and integrin ß3 (CD61) associate to form the heterodimer integrin a2bb3 (CD41/CD61; GPIIb/IIIa), a fibronectin receptor expressed in platelets. P256 has potential use for imaging of thrombi. P256 induces aggregation of normal platelets in plasma.
Host Mouse
Immunogen Peripheral blood mononuclear cells
Subclass IgG1
Molecular Weight (kDa) 135
Myeloma Used P3/NS1/1-Ag4.1
Recommended Growing Conditions DMEM + 5% FCS
Strain Balb/c
Research Area Cancer

References: 4 entries

Bachelot et al. 1990. Eur J Biochem. 190(1):177-83. PMID: 2364945.

1989. Ann. Meeting Br. Nuclear Med. Soc. Abstracts. 243.

Lavender et al. 1988. Nucl Med Commun. 9(10):817-22. PMID: 3211440.

Bai et al. 1984. Blood. 64(1):139-46. PMID: 6234033.

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References: 4 entries

Bachelot et al. 1990. Eur J Biochem. 190(1):177-83. PMID: 2364945.

1989. Ann. Meeting Br. Nuclear Med. Soc. Abstracts. 243.

Lavender et al. 1988. Nucl Med Commun. 9(10):817-22. PMID: 3211440.

Bai et al. 1984. Blood. 64(1):139-46. PMID: 6234033.

IP


Add a reference

References: 4 entries

Bachelot et al. 1990. Eur J Biochem. 190(1):177-83. PMID: 2364945.

1989. Ann. Meeting Br. Nuclear Med. Soc. Abstracts. 243.

Lavender et al. 1988. Nucl Med Commun. 9(10):817-22. PMID: 3211440.

Bai et al. 1984. Blood. 64(1):139-46. PMID: 6234033.

IP


Add a reference


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