Cancer Research Technology
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Catalogue Number 151138
Applications IHC IF IP WB
Antigen/Gene or Protein Targets Integrin a2bß3 (CD41 & CD61)
Synonyms alpha 2B/beta3, alphaIIbetabeta3, GPIIbetabeta3, CD41/CD61, platelet fibronectin receptor
Reactivity Human
Relevance Integrins are heterodimeric cell surface receptors composed of a and ß subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin a2b (CD41) and integrin ß3 (CD61) associate to form the heterodimer integrin a2bb3 (CD41/CD61; GPIIb/IIIa), a fibronectin receptor expressed in platelets. P256 has potential use for imaging of thrombi. P256 induces aggregation of normal platelets in plasma.
Host Mouse
Immunogen Peripheral blood mononuclear cells
Subclass IgG1
Molecular Weight (kDa) 135
Myeloma Used P3/NS1/1-Ag4.1
Recommended Growing Conditions DMEM + 5% FCS
Strain Balb/c
Research Area Cancer

References: 7 entries

Bachelot et al. 1990. Eur J Biochem. 190(1):177-83. PMID: 2364945.

Activation of platelets induced by mAb P256 specific for glycoprotein IIb-IIIa. Possible evidence for a role for IIb-IIIa in membrane signal transduction.

Europe PMC ID: 2364945

1989. Ann. Meeting Br. Nuclear Med. Soc. Abstracts. 243.

Lavender et al. 1988. Nucl Med Commun. 9(10):817-22. PMID: 3211440.

In vivo studies with an anti-platelet monoclonal antibody; P256.

Europe PMC ID: 3211440

Bai et al. 1984. Blood. 64(1):139-46. PMID: 6234033.

IP

Monoclonal antibodies specific for platelet glycoproteins react with human monocytes.

Europe PMC ID: 6234033


Add a reference

References: 7 entries

Bachelot et al. 1990. Eur J Biochem. 190(1):177-83. PMID: 2364945.

Activation of platelets induced by mAb P256 specific for glycoprotein IIb-IIIa. Possible evidence for a role for IIb-IIIa in membrane signal transduction.

Europe PMC ID: 2364945

1989. Ann. Meeting Br. Nuclear Med. Soc. Abstracts. 243.

Lavender et al. 1988. Nucl Med Commun. 9(10):817-22. PMID: 3211440.

In vivo studies with an anti-platelet monoclonal antibody; P256.

Europe PMC ID: 3211440

Bai et al. 1984. Blood. 64(1):139-46. PMID: 6234033.

IP

Monoclonal antibodies specific for platelet glycoproteins react with human monocytes.

Europe PMC ID: 6234033


Add a reference

References: 7 entries

Bachelot et al. 1990. Eur J Biochem. 190(1):177-83. PMID: 2364945.

Activation of platelets induced by mAb P256 specific for glycoprotein IIb-IIIa. Possible evidence for a role for IIb-IIIa in membrane signal transduction.

1989. Ann. Meeting Br. Nuclear Med. Soc. Abstracts. 243.

Lavender et al. 1988. Nucl Med Commun. 9(10):817-22. PMID: 3211440.

In vivo studies with an anti-platelet monoclonal antibody; P256.

Bai et al. 1984. Blood. 64(1):139-46. PMID: 6234033.

IP

Monoclonal antibodies specific for platelet glycoproteins react with human monocytes.


Add a reference


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