Anti-FGF3 [MSD1]
Invented at Cancer Research UK London Research Institute: Lincoln's Inn Fields
- Datasheet
- References (6)
- Inventor Info
Info
| Catalogue Number | 151135 |
| Applications | IHC IF IP WB |
| Antigen/Gene or Protein Targets | Fibroblast Growth Factor-3 (FGF3; Int2) |
| Reactivity | Human, Mouse and Xenopus laevis |
| Relevance |
Monoclonal antibody directed against FGF-3, key for investigating breast carcinogenesis resulting from MMTV. Background and Research Application Fibroblast growth factors (FGFs) can stimulate the proliferation of mesenchymal, epithelial and neuroectodermal cells. FGF3 belongs to the heparin binding growth factors family and is a member of the angiogenic fibroblast growth factor family. FGF3 is an oncogene frequently activated in mammary carcinomas resulting from the chromosomal integration of the mouse mammary tumour virus (MMTV). FGF-3 is implicated in breast carcinogenesis and mammalian development. |
| Host | Mouse |
| Immunogen | Peptide conjugated to BSA. |
| Immunogen UniProt ID | P11487 |
| Subclass | IgG2a |
| Molecular Weight (kDa) | 27 |
| Myeloma Used | P3/NS1/1-Ag4.1 |
| Recommended Growing Conditions | DMEM + 5% FCS |
| Strain | Balb/c |
| Notes |
Production Details Purified using multi-step affinity chromatography with protein A. Storage Conditions Store at -20 degrees frozen. Avoid repeated freeze/thaw cycles. Points of Interest This antibody recognizes all naturally occurring FGF3 variants and all recombinant FGF3 proteins. Concentration 1mg/ml as standard |
| Research Area | Cancer, Cardiovascular, Cell Signaling & Signal Transduction, Virology |
References: 6 entries
Cases et al. 2013. J Biol Chem. 288(23):16655-70. PMID: 23592779.
Cubilin, a high affinity receptor for fibroblast growth factor 8, is required for cell survival in the developing vertebrate head.
Europe PMC ID: 23592779
Vos et al. 2003. J Biol Chem. 278(30):28045-51. PMID: 12732644.
RASSF2 is a novel K-Ras-specific effector and potential tumor suppressor.
Europe PMC ID: 12732644
Antoine et al. 2000. Cell Growth Differ. 11(11):593-605. PMID: 11095248.
NH2-terminal cleavage of xenopus fibroblast growth factor 3 is necessary for optimal biological activity and receptor binding.
Europe PMC ID: 11095248
Add a reference
References: 6 entries
Cases et al. 2013. J Biol Chem. 288(23):16655-70. PMID: 23592779.
Cubilin, a high affinity receptor for fibroblast growth factor 8, is required for cell survival in the developing vertebrate head.
Vos et al. 2003. J Biol Chem. 278(30):28045-51. PMID: 12732644.
RASSF2 is a novel K-Ras-specific effector and potential tumor suppressor.
Antoine et al. 2000. Cell Growth Differ. 11(11):593-605. PMID: 11095248.
NH2-terminal cleavage of xenopus fibroblast growth factor 3 is necessary for optimal biological activity and receptor binding.
Add a reference
