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Anti-FGF3 [MSD1]
RECENTLY UPDATED

Info

Catalogue Number 151135
Applications IHC IF IP WB
Antigen/Gene or Protein Targets Fibroblast Growth Factor-3 (FGF3; Int2)
Reactivity Human, Mouse and Xenopus laevis
Relevance
RECENTLY UPDATED
Monoclonal antibody directed against FGF-3, key for investigating breast carcinogenesis resulting from MMTV.

Background and Research Application
Fibroblast growth factors (FGFs) can stimulate the proliferation of mesenchymal, epithelial and neuroectodermal cells. FGF3 belongs to the heparin binding growth factors family and is a member of the angiogenic fibroblast growth factor family. FGF3 is an oncogene frequently activated in mammary carcinomas resulting from the chromosomal integration of the mouse mammary tumour virus (MMTV). FGF-3 is implicated in breast carcinogenesis and mammalian development.
Host Mouse
Immunogen Peptide conjugated to BSA.
Immunogen UniProt ID
RECENTLY UPDATED
P11487
Subclass IgG2a
Molecular Weight (kDa) 27
Myeloma Used P3/NS1/1-Ag4.1
Recommended Growing Conditions DMEM + 5% FCS
Strain Balb/c
Notes
RECENTLY UPDATED
Production Details
Purified using multi-step affinity chromatography with protein A.

Storage Conditions
Store at -20 degrees frozen. Avoid repeated freeze/thaw cycles.

Points of Interest
This antibody recognizes all naturally occurring FGF3 variants and all recombinant FGF3 proteins.

Concentration
1mg/ml as standard
Research Area
RECENTLY UPDATED
Cancer, Cardiovascular, Cell Signaling & Signal Transduction, Virology

References

There are 6 reference entries for this reagent.

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References: 6 entries
RECENTLY UPDATED

Cases et al. 2013. J Biol Chem. 288(23):16655-70. PMID: 23592779.

Cubilin, a high affinity receptor for fibroblast growth factor 8, is required for cell survival in the developing vertebrate head.

Europe PMC ID: 23592779

Vos et al. 2003. J Biol Chem. 278(30):28045-51. PMID: 12732644.

RASSF2 is a novel K-Ras-specific effector and potential tumor suppressor.

Europe PMC ID: 12732644

Antoine et al. 2000. Cell Growth Differ. 11(11):593-605. PMID: 11095248.

NH2-terminal cleavage of xenopus fibroblast growth factor 3 is necessary for optimal biological activity and receptor binding.

Europe PMC ID: 11095248


Add a reference

References: 6 entries
RECENTLY UPDATED

Cases et al. 2013. J Biol Chem. 288(23):16655-70. PMID: 23592779.

Cubilin, a high affinity receptor for fibroblast growth factor 8, is required for cell survival in the developing vertebrate head.

Vos et al. 2003. J Biol Chem. 278(30):28045-51. PMID: 12732644.

RASSF2 is a novel K-Ras-specific effector and potential tumor suppressor.

Antoine et al. 2000. Cell Growth Differ. 11(11):593-605. PMID: 11095248.

NH2-terminal cleavage of xenopus fibroblast growth factor 3 is necessary for optimal biological activity and receptor binding.


Add a reference

Inventor Information