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Anti-Keratin7 [LP5K]


Catalogue Number 151127
Applications FACS IHC IF WB
Antigen/Gene or Protein Targets Keratin 7
Reactivity Human
Relevance Keratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratins 9 to 23) and one type II keratin (keratins 1 to 8). Keratins demonstrate tissue and differentiation specific expression profiles. Keratins 7 and 8 are two closely related type II keratins characteristic of simple epithelia. Keratin 7 is less widespread than keratin 8 and is expressed in sebaceous and sweat glands and some cells of the inner hair root sheath. Keratin 7 is often co-expressed with keratin 19.
Host Mouse
Immunogen Sonicated cytoskeleton fractions (insoluble in 1% Nonidet-P40) from SV40 transformed neonatal keratinocytes.
Subclass IgG2b
Molecular Weight (kDa) 54
Myeloma Used Sp2/0-Ag14
Recommended Growing Conditions DMEM + 5% FCS
Strain Balb/c
Notes Reacts with human keratin 7 & 8
Research Area Cell Signaling & Signal Transduction

References: 4 entries

Lane EB et al. 1985. Ann. NY Acad. Sci. 455:241-58.PMID: 2417515

Sato et al. 2005. Blood. 106(2):428-35. PMID: 15797992.

Sato et al. 2003. Development. 130(22):5519-32. PMID: 14530297.

Markey et al. 1991. J Invest Dermatol. 97(5):763-70. PMID: 1717607.

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