Anti-Keratin8 [LP3K]
Invented by Prof Birgit Lane from A*STAR Accelerate Technologies Pte Ltd
Invented at Queen Mary University of London
- Datasheet
- References (6)
- Inventor Info
Info
| Catalogue Number | 151126 |
| Applications | IHC IF WB |
| Antigen/Gene or Protein Targets | Keratin 8 |
| Reactivity | Human |
| Relevance | Keratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratins 9 to 23) and one type II keratin (keratins 1 to 8). Keratins demonstrate tissue and differentiation specific expression profiles. Keratins 8 and 18 are two of the first keratins expressed in the embryo, and persist into adult tissues as the keratin pair representing minimal epithelial keratin expression. Keratins 8 and 18 are major components of all simple epithelia (but not of stratified squamous epithelia) and adenocarcinomas. Keratin 8 is the tissue polypeptide antigen (TPA) reported to be present in the serum of cancer patients. |
| Host | Mouse |
| Immunogen | Sonicated cytoskeleton fractions (insoluble in 1% Nonidet-P40) from SV40 transformed neonatal keratinocytes. |
| Subclass | IgG1 |
| Molecular Weight (kDa) | 52 |
| Myeloma Used | Sp2/0-Ag14 |
| Recommended Growing Conditions | DMEM + 5% FCS |
| Strain | Balb/c |
| Research Area | Cell Signaling & Signal Transduction |
References: 6 entries
Waseem et al. 2004. Biochemistry. 43(5):1283-95. PMID: 14756564.
Conformational changes in the rod domain of human keratin 8 following heterotypic association with keratin 18 and its implication for filament stability.
Europe PMC ID: 14756564
Godsave et al. 1986. J Embryol Exp Morphol. 97:201-23. PMID: 2432146.
The appearance and distribution of intermediate filament proteins during differentiation of the central nervous system, skin and notochord of Xenopus laevis.
Europe PMC ID: 2432146
Lane et al. 1985. Ann N Y Acad Sci. 455:241-58. PMID: 2417515.
Keratin antigens in differentiating skin.
Europe PMC ID: 2417515
Add a reference
References: 6 entries
Waseem et al. 2004. Biochemistry. 43(5):1283-95. PMID: 14756564.
Conformational changes in the rod domain of human keratin 8 following heterotypic association with keratin 18 and its implication for filament stability.
Godsave et al. 1986. J Embryol Exp Morphol. 97:201-23. PMID: 2432146.
The appearance and distribution of intermediate filament proteins during differentiation of the central nervous system, skin and notochord of Xenopus laevis.
Lane et al. 1985. Ann N Y Acad Sci. 455:241-58. PMID: 2417515.
Keratin antigens in differentiating skin.
Add a reference
