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Anti-Keratin7 [LP1K]


Catalogue Number 151124
Applications IHC IF WB
Antigen/Gene or Protein Targets Keratin 7
Reactivity Mammalian and Xenopus laevis
Relevance Keratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratins 9 to 23) and one type II keratin (keratins 1 to 8). Keratins demonstrate tissue and differentiation specific expression profiles. Keratins 7 and 8 are two closely related type II keratins characteristic of simple epithelia. Keratin 7 is less widespread than keratin 8 and is expressed in sebaceous and sweat glands and some cells of the inner hair root sheath. Keratin 7 is often co-expressed with keratin 19. LP1K has some weak reactivity with keratin 8 and other type II keratins.
Host Mouse
Immunogen Sonicated cytoskeleton fractions (insoluble in 1% Nonidet-P40) from SV40 transformed neonatal keratinocytes.
Subclass IgG1
Molecular Weight (kDa) 54
Myeloma Used Sp2/0-Ag14
Recommended Growing Conditions DMEM + 5% FCS
Strain Balb/c
Notes Not recommended for fixed tissue immunohistochemistry.
Research Area Cell Signaling & Signal Transduction

References: 4 entries

Lane EB et al. 1985. Ann. NY Acad. Sci. 455:241-58.PMID: 2417515

Zhang et al. 2013. Cell Death Dis. 4:e502. PMID: 23429288.

Zhang et al. 2012. PLoS One. 7(6):e38487. PMID: 22679510.

Markey et al. 1992. Br J Dermatol. 126(2):154-60. PMID: 1371396.

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