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Anti-MCSP [LHM 2]

Info

Catalogue Number 151118
Applications FACS IHC IF IP WB
Antigen/Gene or Protein Targets Melanoma associated Chondroitin Sulphate Proteoglycan (MCSP or NG2)
Reactivity Human
Relevance The LHM2 antibody is a very good marker for melanoma (>90% stained). LHM2 also stains basal cell carcinomas and subpopulation of basal keratinocytes. LHM2 can be used as a diagnostic panel for immunopathology of malignant melanoma and potential candidates for immunoimaging and immunotherapy of disseminated melanoma. The originators of this antibody report that the MCSP is a cell surface marker specific for epidermal stem cells (J. Invest. Dermatol. in press). Potential applications of the LHM2 antibody include use for separation/isolation of epidermal stem cells, detection of stem cells in skin biopsies or epithelial cell cultures and optimisation of culture conditions to retain epidermal stem cell population in in vitro cultures.
Host Mouse
Immunogen A 375P cells crude extract.
Subclass IgG1 kappa
Molecular Weight (kDa) 240
Myeloma Used NS0
Recommended Growing Conditions DMEM + 5% FCS
Research Area Adhesion, Cancer, Cell Type or Organelle Marker, Neurobiology

References: 8 entries

Somaiah et al. 2012. Clin Cancer Res. 18(19):5479-88. PMID: 22855580.

The relationship between homologous recombination repair and the sensitivity of human epidermis to the size of daily doses over a 5-week course of breast radiotherapy.

Europe PMC ID: 22855580

Ghali et al. 2004. J Invest Dermatol. 122(2):433-42. PMID: 15009727.

Epidermal and hair follicle progenitor cells express melanoma-associated chondroitin sulfate proteoglycan core protein.

Europe PMC ID: 15009727

Kupsch et al. 1999. Clin Cancer Res. 5(4):925-31. PMID: 10213230.

Isolation of human tumor-specific antibodies by selection of an antibody phage library on melanoma cells.

Europe PMC ID: 10213230

Kupsch et al. 1995. Melanoma Res. 5(6):403-11. PMID: 8589614.

Generation and selection of monoclonal antibodies, single-chain Fv and antibody fusion phage specific for human melanoma-associated antigens.

Europe PMC ID: 8589614


Add a reference

References: 8 entries

Somaiah et al. 2012. Clin Cancer Res. 18(19):5479-88. PMID: 22855580.

The relationship between homologous recombination repair and the sensitivity of human epidermis to the size of daily doses over a 5-week course of breast radiotherapy.

Europe PMC ID: 22855580

Ghali et al. 2004. J Invest Dermatol. 122(2):433-42. PMID: 15009727.

Epidermal and hair follicle progenitor cells express melanoma-associated chondroitin sulfate proteoglycan core protein.

Europe PMC ID: 15009727

Kupsch et al. 1999. Clin Cancer Res. 5(4):925-31. PMID: 10213230.

Isolation of human tumor-specific antibodies by selection of an antibody phage library on melanoma cells.

Europe PMC ID: 10213230

Kupsch et al. 1995. Melanoma Res. 5(6):403-11. PMID: 8589614.

Generation and selection of monoclonal antibodies, single-chain Fv and antibody fusion phage specific for human melanoma-associated antigens.

Europe PMC ID: 8589614


Add a reference

References: 8 entries

Somaiah et al. 2012. Clin Cancer Res. 18(19):5479-88. PMID: 22855580.

The relationship between homologous recombination repair and the sensitivity of human epidermis to the size of daily doses over a 5-week course of breast radiotherapy.

Ghali et al. 2004. J Invest Dermatol. 122(2):433-42. PMID: 15009727.

Epidermal and hair follicle progenitor cells express melanoma-associated chondroitin sulfate proteoglycan core protein.

Kupsch et al. 1999. Clin Cancer Res. 5(4):925-31. PMID: 10213230.

Isolation of human tumor-specific antibodies by selection of an antibody phage library on melanoma cells.

Kupsch et al. 1995. Melanoma Res. 5(6):403-11. PMID: 8589614.

Generation and selection of monoclonal antibodies, single-chain Fv and antibody fusion phage specific for human melanoma-associated antigens.


Add a reference


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