Anti-PLAP [HD 11F7]
Invented by Prof Walter Bodmer at Cancer Research UK London Research Institute: Lincoln's Inn Fields
- Datasheet
- References (2)
- Inventor Info
Info
| Catalogue Number | 151106 |
| Applications | ELISA IHC RIA |
| Antigen/Gene or Protein Targets | Placental alkaline phosphatase (PLAP) |
| Reactivity | Human |
| Relevance | Alkaline phosphatases are phosphodiesterases. The placental-specific isozyme of Alkaline Phosphatase (PLAP) is found in trophoblast cells of normal human mature placenta, seminomas of testis and ovarian carcinomas. The detection of alkaline phosphatase in serum is a marker for ovarian and testicular cancer. HD 11F7 has potential uses in the diagnosis of ovarian and testicular tumours. The antibody detects both Regan and Nagao isoenzymes. |
| Host | Mouse |
| Immunogen | Fresh Hep-2 cells followed by booster injections of fresh Hep-2 cells that had their surface expression of PLAP boosted in culture. |
| Subclass | IgG2b |
| Myeloma Used | P3/NS1/1-Ag4.1 |
| Recommended Growing Conditions | DMEM + 5% FCS |
| Strain | Balb/c |
| Research Area | Cancer, Cell Type or Organelle Marker |
References: 2 entries
Durbin et al. 1988. Int J Cancer Suppl. 2:59-66. PMID: 3162446.
Monoclonal antibodies to placental alkaline phosphatase: preclinical evaluation in a human xenograft tumour model of F(ab')2 and Fab fragments.
Europe PMC ID: 3162446
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References: 2 entries
Durbin et al. 1988. Int J Cancer Suppl. 2:59-66. PMID: 3162446.
Monoclonal antibodies to placental alkaline phosphatase: preclinical evaluation in a human xenograft tumour model of F(ab')2 and Fab fragments.
Add a reference
