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Anti-PLAP [HD 11F7]


Catalogue Number 151106
Applications ELISA IHC RIA
Antigen/Gene or Protein Targets Placental alkaline phosphatase (PLAP)
Reactivity Human
Relevance Alkaline phosphatases are phosphodiesterases. The placental-specific isozyme of Alkaline Phosphatase (PLAP) is found in trophoblast cells of normal human mature placenta, seminomas of testis and ovarian carcinomas. The detection of alkaline phosphatase in serum is a marker for ovarian and testicular cancer. HD 11F7 has potential uses in the diagnosis of ovarian and testicular tumours. The antibody detects both Regan and Nagao isoenzymes.
Host Mouse
Immunogen Fresh Hep-2 cells followed by booster injections of fresh Hep-2 cells that had their surface expression of PLAP boosted in culture.
Subclass IgG2b
Myeloma Used P3/NS1/1-Ag4.1
Recommended Growing Conditions DMEM + 5% FCS
Strain Balb/c
Research Area Cancer, Cell Type or Organelle Marker

References: 1 entry

Durbin et al. 1988. Int J Cancer Suppl. 2:59-66. PMID: 3162446.

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