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Anti-Integrin a2 [HAS-3]

Invented by Prof Fiona Watt at King's College London

Info

Catalogue Number 151104
Applications FACS IHC IF IP
Antigen/Gene or Protein Targets Integrin a2 (CD49b)
Synonyms Integrin Subunit Alpha 2; Alpha 2 Subunit Of VLA-2 Receptor; Platelet Membrane Glycoprotein Ia; CD49 Antigen-Like Family Member B; Collagen Receptor; CD49B; GPIa; Very Late Activation Protein 2 Receptor, Alpha-2 Subunit; Human Platelet Alloantigen System 5; Platelet Glycoprotein GPIa; Platelet Antigen Br; VLA-2 Subunit Alpha; CD49b Antigen; HPA-5; VLA-2; VLAA2; BR
Reactivity Human
Relevance Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin a2 associates with integrin ß1 (CD29) to form the heterodimer integrin a2ß1, which is one of the most abundant keratinocyte integrins, is found distributed in the basal layer of epidermis and binds collagen. HAS-3 co-precipitates integrin a2ß1 from keratinocytes and inhibits HGF-induced branching morphogenesis and motility of human mammary epithelial HB2 cells in collagen.
Host Mouse
Immunogen Whole human keratinocytes.
Subclass IgG2a
Myeloma Used Sp2/0-Ag14
Recommended Growing Conditions DMEM + 10% FCS
Research Area Adhesion, Cancer, Cell Signaling & Signal Transduction, Metabolism

References: 10 entries

Activation of c-MET induces a stem-like phenotype in human prostate cancer.

Europe PMC ID: 22110593

van Leenders et al. 2011. PLoS One. 6(11):e26753. PMID: 22110593.

Teklemariam et al. 2011. Toxicon. 57(5):646-56. PMID: 21255601.

Functional analysis of a recombinant PIII-SVMP, GST-acocostatin; an apoptotic inducer of HUVEC and HeLa, but not SK-Mel-28 cells.

Europe PMC ID: 21255601

Singh et al. 2010. Am J Physiol Lung Cell Mol Physiol. 299(2):L169-83. PMID: 20435685.

Can lineage-specific markers be identified to characterize mesenchyme-derived cell populations in the human airways?

Europe PMC ID: 20435685

Alford et al. 1998. J Cell Sci. 111 ( Pt 4):521-32. PMID: 9443900.

Integrin-matrix interactions affect the form of the structures developing from human mammary epithelial cells in collagen or fibrin gels.

Europe PMC ID: 9443900

Tenchini et al. 1993. Cell Adhes Commun. 1(1):55-66. PMID: 7521749.

Evidence against a major role for integrins in calcium-dependent intercellular adhesion of epidermal keratinocytes.

Europe PMC ID: 7521749


Add a reference

References: 10 entries

Activation of c-MET induces a stem-like phenotype in human prostate cancer.

Europe PMC ID: 22110593

van Leenders et al. 2011. PLoS One. 6(11):e26753. PMID: 22110593.

Teklemariam et al. 2011. Toxicon. 57(5):646-56. PMID: 21255601.

Functional analysis of a recombinant PIII-SVMP, GST-acocostatin; an apoptotic inducer of HUVEC and HeLa, but not SK-Mel-28 cells.

Europe PMC ID: 21255601

Singh et al. 2010. Am J Physiol Lung Cell Mol Physiol. 299(2):L169-83. PMID: 20435685.

Can lineage-specific markers be identified to characterize mesenchyme-derived cell populations in the human airways?

Europe PMC ID: 20435685

Alford et al. 1998. J Cell Sci. 111 ( Pt 4):521-32. PMID: 9443900.

Integrin-matrix interactions affect the form of the structures developing from human mammary epithelial cells in collagen or fibrin gels.

Europe PMC ID: 9443900

Tenchini et al. 1993. Cell Adhes Commun. 1(1):55-66. PMID: 7521749.

Evidence against a major role for integrins in calcium-dependent intercellular adhesion of epidermal keratinocytes.

Europe PMC ID: 7521749


Add a reference

References: 10 entries

Activation of c-MET induces a stem-like phenotype in human prostate cancer.

van Leenders et al. 2011. PLoS One. 6(11):e26753. PMID: 22110593.

Teklemariam et al. 2011. Toxicon. 57(5):646-56. PMID: 21255601.

Functional analysis of a recombinant PIII-SVMP, GST-acocostatin; an apoptotic inducer of HUVEC and HeLa, but not SK-Mel-28 cells.

Singh et al. 2010. Am J Physiol Lung Cell Mol Physiol. 299(2):L169-83. PMID: 20435685.

Can lineage-specific markers be identified to characterize mesenchyme-derived cell populations in the human airways?

Alford et al. 1998. J Cell Sci. 111 ( Pt 4):521-32. PMID: 9443900.

Integrin-matrix interactions affect the form of the structures developing from human mammary epithelial cells in collagen or fibrin gels.

Tenchini et al. 1993. Cell Adhes Commun. 1(1):55-66. PMID: 7521749.

Evidence against a major role for integrins in calcium-dependent intercellular adhesion of epidermal keratinocytes.


Add a reference


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