Anti-Leu1 [H65]
Invented by Prof Walter Bodmer from University of Oxford
Invented at Cancer Research UK London Research Institute: Lincoln's Inn Fields
- Datasheet
- References (1)
- Inventor Info
Info
| Catalogue Number | 151103 |
| Applications | IHC IF IP RIA WB |
| Antigen/Gene or Protein Targets | Leu1 (CD5) |
| Synonyms | CD5 Molecule 2; Lymphocyte Antigen T1/Leu-1; LEU1; CD5 Antigen; T1 |
| Reactivity | Human |
| Relevance | CD5 is a good immunohistochemical marker for T-cells, although not as sensitive as CD3: it was used as a T-cell marker until monoclonal antibodies against CD3 were developed (see our UCHT1 anti-CD3 antibody). It is found in 76% of T-cells neoplasms, but also in diffuse large B cell lymphoma, chronic lymphocytic leukemia, hairy cell leukemia, and mantle cell lymphoma cells. It is commonly lost in cutaneous T-cell lymphoma, and its absence can be used as an indicator of malignancy in this condition. |
| Host | Mouse |
| Immunogen | HSB-2 cells. |
| Subclass | IgG1 |
| Myeloma Used | P3/NS1/1-Ag4.1 |
| Recommended Growing Conditions | DMEM + 5% FCS |
| Strain | Balb/c |
| Research Area | Immunology, Stem Cell Biology |
References: 1 entry
1st International Workshop on Human Leucocyte Differentiation Antigens (CodeT34) Paris. 1982.
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References: 1 entry
1st International Workshop on Human Leucocyte Differentiation Antigens (CodeT34) Paris. 1982.
Add a reference
