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Anti-Leu1 [H65]


Catalogue Number 151103
Applications IHC IF IP RIA WB
Antigen/Gene or Protein Targets Leu1 (CD5)
Synonyms CD5 Molecule 2; Lymphocyte Antigen T1/Leu-1; LEU1; CD5 Antigen; T1
Reactivity Human
Relevance CD5 is a good immunohistochemical marker for T-cells, although not as sensitive as CD3: it was used as a T-cell marker until monoclonal antibodies against CD3 were developed (see our UCHT1 anti-CD3 antibody). It is found in 76% of T-cells neoplasms, but also in diffuse large B cell lymphoma, chronic lymphocytic leukemia, hairy cell leukemia, and mantle cell lymphoma cells. It is commonly lost in cutaneous T-cell lymphoma, and its absence can be used as an indicator of malignancy in this condition.
Host Mouse
Immunogen HSB-2 cells.
Subclass IgG1
Myeloma Used P3/NS1/1-Ag4.1
Recommended Growing Conditions DMEM + 5% FCS
Strain Balb/c
Research Area Immunology, Stem Cell Biology

References: 1 entry

1st International Workshop on Human Leucocyte Differentiation Antigens (CodeT34) Paris. 1982.

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