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Anti-Integrin a3 [F35 177-1]


Catalogue Number 151096
Applications IHC IF
Antigen/Gene or Protein Targets Integrin a3 (CD49c)
Reactivity Human
Relevance Integrins are heterodimeric cell surface receptors composed of a and b subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin a3 is found on most cell types. Integrin a3 associates with b1 integrin to form integrin a3b1, which is one of the most abundant keratinocyte integrins and binds laminin 5.
Host Mouse
Immunogen MTSV1-7 HYE - human breast epithelial cells.
Subclass IgG1
Myeloma Used P3X63Ag8.653
Recommended Growing Conditions DMEM + 5% FCS
Strain Balb/c
Research Area Adhesion, Cancer

References: 3 entries

Lustosa et al. 2014. ScientificWorldJournal. 2014:102541. PMID: 24737953.

McInroy et al. 2011. Exp Cell Res. 317(17):2468-78. PMID: 21821021.

Gaggioli et al. 2007. Nat Cell Biol. 9(12):1392-400. PMID: 18037882.

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