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Catalogue Number 151083
Applications IHC IP WB
Antigen/Gene or Protein Targets Human Papilloma Virus-16 and 18 early protein 6 (HPV16E6 & HPV18 E6)
Reactivity Human papilloma virus
Relevance The human papilloma virus (HPV) family of DNA tumor viruses includes HPV-16 and HPV-18, which are associated with a large proportion of cervical cancer cases. HPV early proteins E6 and E7 are the major viral oncoproteins that regulate cell proliferation through the inactivation of p53 and Rb1 tumour suppressor proteins respectively. C1P5 can be used for detection of HPV in cervical smears and biopsies and analysis of E6 expression in cell transformation studies.
Host Mouse
Immunogen Gel-purified HPV-18 E6-beta galactosidase fusion protein
Subclass IgG1
Myeloma Used P3/NS1/1-Ag4.1
Recommended Growing Conditions DMEM + 5% FCS
Strain Balb/c
Notes Reacts with HPV infected human cells
Research Area Cancer, Virology

References: 10 entries

Xie et al. 2014. Oncogene. 33(8):1037-46. PMID: 23474763.

Targeting HPV16 E6-p300 interaction reactivates p53 and inhibits the tumorigenicity of HPV-positive head and neck squamous cell carcinoma.

Europe PMC ID: 23474763

Herfs et al. 2012. Proc Natl Acad Sci U S A. 109(26):10516-21. PMID: 22689991.

A discrete population of squamocolumnar junction cells implicated in the pathogenesis of cervical cancer.

Europe PMC ID: 22689991

Lawson et al. 2009. Br J Cancer. 101(8):1351-6. PMID: 19773762.

Koilocytes indicate a role for human papilloma virus in breast cancer.

Europe PMC ID: 19773762

Zhang et al. 2005. J Biol Chem. 280(39):33165-77. PMID: 15983032.

BRCA1 interaction with human papillomavirus oncoproteins.

Europe PMC ID: 15983032

Banks et al. 1987. J Gen Virol. 68 ( Pt 5):1351-9. PMID: 3033140.

Identification of human papillomavirus type 18 E6 polypeptide in cells derived from human cervical carcinomas.

Europe PMC ID: 3033140


Add a reference

References: 10 entries

Xie et al. 2014. Oncogene. 33(8):1037-46. PMID: 23474763.

Targeting HPV16 E6-p300 interaction reactivates p53 and inhibits the tumorigenicity of HPV-positive head and neck squamous cell carcinoma.

Europe PMC ID: 23474763

Herfs et al. 2012. Proc Natl Acad Sci U S A. 109(26):10516-21. PMID: 22689991.

A discrete population of squamocolumnar junction cells implicated in the pathogenesis of cervical cancer.

Europe PMC ID: 22689991

Lawson et al. 2009. Br J Cancer. 101(8):1351-6. PMID: 19773762.

Koilocytes indicate a role for human papilloma virus in breast cancer.

Europe PMC ID: 19773762

Zhang et al. 2005. J Biol Chem. 280(39):33165-77. PMID: 15983032.

BRCA1 interaction with human papillomavirus oncoproteins.

Europe PMC ID: 15983032

Banks et al. 1987. J Gen Virol. 68 ( Pt 5):1351-9. PMID: 3033140.

Identification of human papillomavirus type 18 E6 polypeptide in cells derived from human cervical carcinomas.

Europe PMC ID: 3033140


Add a reference

References: 10 entries

Xie et al. 2014. Oncogene. 33(8):1037-46. PMID: 23474763.

Targeting HPV16 E6-p300 interaction reactivates p53 and inhibits the tumorigenicity of HPV-positive head and neck squamous cell carcinoma.

Herfs et al. 2012. Proc Natl Acad Sci U S A. 109(26):10516-21. PMID: 22689991.

A discrete population of squamocolumnar junction cells implicated in the pathogenesis of cervical cancer.

Lawson et al. 2009. Br J Cancer. 101(8):1351-6. PMID: 19773762.

Koilocytes indicate a role for human papilloma virus in breast cancer.

Zhang et al. 2005. J Biol Chem. 280(39):33165-77. PMID: 15983032.

BRCA1 interaction with human papillomavirus oncoproteins.

Banks et al. 1987. J Gen Virol. 68 ( Pt 5):1351-9. PMID: 3033140.

Identification of human papillomavirus type 18 E6 polypeptide in cells derived from human cervical carcinomas.


Add a reference


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