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|Applications||IHC IP WB|
|Antigen/Gene or Protein Targets||Human Papilloma Virus-16 and 18 early protein 6 (HPV16E6 & HPV18 E6)|
|Reactivity||Human papilloma virus|
|Relevance||The human papilloma virus (HPV) family of DNA tumor viruses includes HPV-16 and HPV-18, which are associated with a large proportion of cervical cancer cases. HPV early proteins E6 and E7 are the major viral oncoproteins that regulate cell proliferation through the inactivation of p53 and Rb1 tumour suppressor proteins respectively. C1P5 can be used for detection of HPV in cervical smears and biopsies and analysis of E6 expression in cell transformation studies.|
|Immunogen||Gel-purified HPV-18 E6-beta galactosidase fusion protein|
|Recommended Growing Conditions||DMEM + 5% FCS|
|Notes||Reacts with HPV infected human cells|
|Research Area||Cancer, Virology|
References: 5 entries
Xie et al. 2014. Oncogene. 33(8):1037-46. PMID: 23474763.
Herfs et al. 2012. Proc Natl Acad Sci U S A. 109(26):10516-21. PMID: 22689991.
Lawson et al. 2009. Br J Cancer. 101(8):1351-6. PMID: 19773762.
Zhang et al. 2005. J Biol Chem. 280(39):33165-77. PMID: 15983032.
Banks et al. 1987. J Gen Virol. 68 ( Pt 5):1351-9. PMID: 3033140.
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