Anti-Microglobulin ß2 [BBM.1]
Invented by Prof Walter Bodmer from University of Oxford
Invented at University of Oxford
- Datasheet
- References (12)
- Inventor Info
Info
![Image thumbnail for Anti-Microglobulin ß2 [BBM.1]](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,h_45,q_auto/ca55149b-f1d7-41d6-8023-6b950827bcdd.jpg)
![Image thumbnail for Anti-Microglobulin ß2 [BBM.1]](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,h_45,q_auto/43ec6027-de40-4428-9805-81bccdb452d2.jpg)
| Catalogue Number | 151079 |
| Applications | ELISA FACS IHC IP Fn |
| Antigen/Gene or Protein Targets | Microglobulin Beta 2 |
| Reactivity | Human |
| Relevance | Beta2-microglobulin associates with human leucocyte antigens (HLAs). BBM.1 binds significantly with fibroblasts and lymphocytes from humans and primates and can be used for the detection of Beta2-microglobulin in myeloma and other conditions (serum assay kits etc.). BBM.1 binds equivalently to free and HLA-associated Beta2-microglobulin and may be used for detection in myeloma and other conditions (e.g. within serum assay kits). |
| Host | Mouse |
| Immunogen | Molt 4, a human T cell line. |
| Subclass | IgG2b |
| Myeloma Used | P3X63Ag8 |
| Recommended Growing Conditions | DMEM + 5% FCS |
| Strain | Balb/c |
| Research Area | Cancer, Cardiovascular |
References: 12 entries
Novoselov et al. 2012. Virus Res. 166(1-2):87-96. PMID: 22445689.
Fn
Isolation of primitive endoderm, mesoderm, vascular endothelial and trophoblast progenitors from human pluripotent stem cells.
Europe PMC ID: 22634564
A single amino acid substitution controls DAF-dependent phenotype of echovirus 11 in rhabdomyosarcoma cells.
Europe PMC ID: 22445689
Josson et al. 2011. Cancer Res. 71(7):2600-10. PMID: 21427356.
IHC
β2-microglobulin induces epithelial to mesenchymal transition and confers cancer lethality and bone metastasis in human cancer cells.
Europe PMC ID: 21427356
Du et al. 2009. J Mol Recognit. 22(6):465-73. PMID: 19582797.
ELISA
Parham et al. 1983. J Biol Chem. 258(10):6179-86. PMID: 6189821.
Arginine 45 is a major part of the antigenic determinant of human beta 2-microglobulin recognized by mouse monoclonal antibody BBM.1.
Europe PMC ID: 6189821
Brodsky et al. 1979. Immunol Rev. 47:3-61. PMID: 95015.
Brodsky et al. 1979. Eur J Immunol. 9(7):536-45. PMID: 91522.
Characterization of a monoclonal anti-beta 2-microglobulin antibody and its use in the genetic and biochemical analysis of major histocompatibility antigens.
Europe PMC ID: 91522
Monoclonal antibodies for analysis of the HLA system.
Europe PMC ID: 95015
Add a reference
References: 12 entries
Novoselov et al. 2012. Virus Res. 166(1-2):87-96. PMID: 22445689.
Fn
Isolation of primitive endoderm, mesoderm, vascular endothelial and trophoblast progenitors from human pluripotent stem cells.
A single amino acid substitution controls DAF-dependent phenotype of echovirus 11 in rhabdomyosarcoma cells.
Josson et al. 2011. Cancer Res. 71(7):2600-10. PMID: 21427356.
IHC
β2-microglobulin induces epithelial to mesenchymal transition and confers cancer lethality and bone metastasis in human cancer cells.
Du et al. 2009. J Mol Recognit. 22(6):465-73. PMID: 19582797.
ELISA
Parham et al. 1983. J Biol Chem. 258(10):6179-86. PMID: 6189821.
Arginine 45 is a major part of the antigenic determinant of human beta 2-microglobulin recognized by mouse monoclonal antibody BBM.1.
Brodsky et al. 1979. Immunol Rev. 47:3-61. PMID: 95015.
Brodsky et al. 1979. Eur J Immunol. 9(7):536-45. PMID: 91522.
Characterization of a monoclonal anti-beta 2-microglobulin antibody and its use in the genetic and biochemical analysis of major histocompatibility antigens.
Monoclonal antibodies for analysis of the HLA system.
Add a reference
