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Anti-Microglobulin ß2 [BBM.1]

Invented by Prof Walter Bodmer at University of Oxford

Info

Catalogue Number 151079
Applications FACS IHC IP Fn
Antigen/Gene or Protein Targets Microglobulin Beta 2
Reactivity Human
Relevance Beta2-microglobulin associates with human leucocyte antigens (HLAs). BBM.1 binds significantly with fibroblasts and lymphocytes from humans and primates and can be used for the detection of Beta2-microglobulin in myeloma and other conditions (serum assay kits etc.). BBM.1 binds equivalently to free and HLA-associated Beta2-microglobulin and may be used for detection in myeloma and other conditions (e.g. within serum assay kits).
Host Mouse
Immunogen Molt 4, a human T cell line.
Subclass IgG2b
Myeloma Used P3X63Ag8
Recommended Growing Conditions DMEM + 5% FCS
Strain Balb/c
Research Area Cancer, Cardiovascular

References: 12 entries

Novoselov et al. 2012. Virus Res. 166(1-2):87-96. PMID: 22445689.

Fn

Drukker et al. 2012. Nat Biotechnol. 30(6):531-42. PMID: 22634564.

FACS

Isolation of primitive endoderm, mesoderm, vascular endothelial and trophoblast progenitors from human pluripotent stem cells.

Europe PMC ID: 22634564

A single amino acid substitution controls DAF-dependent phenotype of echovirus 11 in rhabdomyosarcoma cells.

Europe PMC ID: 22445689

Josson et al. 2011. Cancer Res. 71(7):2600-10. PMID: 21427356.

IHC

β2-microglobulin induces epithelial to mesenchymal transition and confers cancer lethality and bone metastasis in human cancer cells.

Europe PMC ID: 21427356

Parham et al. 1983. J Biol Chem. 258(10):6179-86. PMID: 6189821.

Arginine 45 is a major part of the antigenic determinant of human beta 2-microglobulin recognized by mouse monoclonal antibody BBM.1.

Europe PMC ID: 6189821

Brodsky et al. 1979. Immunol Rev. 47:3-61. PMID: 95015.

Brodsky et al. 1979. Eur J Immunol. 9(7):536-45. PMID: 91522.

Characterization of a monoclonal anti-beta 2-microglobulin antibody and its use in the genetic and biochemical analysis of major histocompatibility antigens.

Europe PMC ID: 91522

Monoclonal antibodies for analysis of the HLA system.

Europe PMC ID: 95015


Add a reference

References: 12 entries

Novoselov et al. 2012. Virus Res. 166(1-2):87-96. PMID: 22445689.

Fn

Drukker et al. 2012. Nat Biotechnol. 30(6):531-42. PMID: 22634564.

FACS

Isolation of primitive endoderm, mesoderm, vascular endothelial and trophoblast progenitors from human pluripotent stem cells.

Europe PMC ID: 22634564

A single amino acid substitution controls DAF-dependent phenotype of echovirus 11 in rhabdomyosarcoma cells.

Europe PMC ID: 22445689

Josson et al. 2011. Cancer Res. 71(7):2600-10. PMID: 21427356.

IHC

β2-microglobulin induces epithelial to mesenchymal transition and confers cancer lethality and bone metastasis in human cancer cells.

Europe PMC ID: 21427356

Parham et al. 1983. J Biol Chem. 258(10):6179-86. PMID: 6189821.

Arginine 45 is a major part of the antigenic determinant of human beta 2-microglobulin recognized by mouse monoclonal antibody BBM.1.

Europe PMC ID: 6189821

Brodsky et al. 1979. Immunol Rev. 47:3-61. PMID: 95015.

Brodsky et al. 1979. Eur J Immunol. 9(7):536-45. PMID: 91522.

Characterization of a monoclonal anti-beta 2-microglobulin antibody and its use in the genetic and biochemical analysis of major histocompatibility antigens.

Europe PMC ID: 91522

Monoclonal antibodies for analysis of the HLA system.

Europe PMC ID: 95015


Add a reference

References: 12 entries

Novoselov et al. 2012. Virus Res. 166(1-2):87-96. PMID: 22445689.

Fn

Drukker et al. 2012. Nat Biotechnol. 30(6):531-42. PMID: 22634564.

FACS

Isolation of primitive endoderm, mesoderm, vascular endothelial and trophoblast progenitors from human pluripotent stem cells.

A single amino acid substitution controls DAF-dependent phenotype of echovirus 11 in rhabdomyosarcoma cells.

Josson et al. 2011. Cancer Res. 71(7):2600-10. PMID: 21427356.

IHC

β2-microglobulin induces epithelial to mesenchymal transition and confers cancer lethality and bone metastasis in human cancer cells.

Parham et al. 1983. J Biol Chem. 258(10):6179-86. PMID: 6189821.

Arginine 45 is a major part of the antigenic determinant of human beta 2-microglobulin recognized by mouse monoclonal antibody BBM.1.

Brodsky et al. 1979. Immunol Rev. 47:3-61. PMID: 95015.

Brodsky et al. 1979. Eur J Immunol. 9(7):536-45. PMID: 91522.

Characterization of a monoclonal anti-beta 2-microglobulin antibody and its use in the genetic and biochemical analysis of major histocompatibility antigens.

Monoclonal antibodies for analysis of the HLA system.


Add a reference


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