- Datasheet
- References (6)
- Inventor Info
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![Image thumbnail for Anti-AP2 (a&b) [A6/2/2]](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,h_45,q_auto/59ffd732-1cc0-4e6b-b76b-34cf39ead465.PNG)
| Catalogue Number | 151069 |
| Applications | ELISA FACS IHC IF RIA WB |
| Antigen/Gene or Protein Targets | Activating Protein 2 (AP-2) alpha and beta forms. |
| Reactivity | Human |
| Relevance | AP-2 is a family of developmentally regulated transcription factors which also play a role in breast cancer and melanoma. AP-2ß may be important in cardiac and kidney development. The AP-2 transcription factors form the OB2 complex that has been shown to up-regulate c-erb-B2 transcription. |
| Host | Mouse |
| Immunogen | Peptide to C-Terminal of AP-2 Alpha coupled to KLH. PNSHTDNNAKSSDKEEKHRK |
| Positive Control | Raji cells or breast carcinomas. |
| Subclass | IgG1 |
| Myeloma Used | NS0 |
| Recommended Growing Conditions | DMEM + 5% FCS |
| Notes | Recommended for immunohistology using formal saline fixative with calcium on paraffin embedded specimens (10min microwave treatment required). |
| Research Area | Cancer, Cardiovascular, Epigenetics & Nuclear Signalling |
References: 6 entries
Yang et al. 2005. J Am Soc Nephrol. 16(10):2890-6. PMID: 16107581.
Redistribution of myosin VI from top to base of proximal tubule microvilli during acute hypertension.
Europe PMC ID: 16107581
Gee et al. 1999. J Pathol. 189(4):514-20. PMID: 10629551.
Immunohistochemical analysis reveals a tumour suppressor-like role for the transcription factor AP-2 in invasive breast cancer.
Europe PMC ID: 10629551
Batsché et al. 1998. Mol Cell Biol. 18(7):3647-58. PMID: 9632747.
RB and c-Myc activate expression of the E-cadherin gene in epithelial cells through interaction with transcription factor AP-2.
Europe PMC ID: 9632747
Add a reference
References: 6 entries
Yang et al. 2005. J Am Soc Nephrol. 16(10):2890-6. PMID: 16107581.
Redistribution of myosin VI from top to base of proximal tubule microvilli during acute hypertension.
Gee et al. 1999. J Pathol. 189(4):514-20. PMID: 10629551.
Immunohistochemical analysis reveals a tumour suppressor-like role for the transcription factor AP-2 in invasive breast cancer.
Batsché et al. 1998. Mol Cell Biol. 18(7):3647-58. PMID: 9632747.
RB and c-Myc activate expression of the E-cadherin gene in epithelial cells through interaction with transcription factor AP-2.
Add a reference
Inventor Information
Inventors
|
Helen Hurst |
