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Anti-BCRABL [7c6]

Info

Catalogue Number 151062
Applications IF IP WB
Antigen/Gene or Protein Targets BCRABL
Reactivity Human
Relevance The BCR gene is involved in the 9:22 translocation that generates the Philadelphia chromosome both in chronic myeloid leukemia (CML) and in a proportion of cases of acute lymphocytic leukemia (ALL). A 5' bcr sequence becomes fused to an abl sequence (including tyrosine kinase domain sequences) from chromosome 9 and results in the production of a chimaeric BCR-ABL protein with enhanced kinase activity. These antibodies may be useful for studies of the oncogene and have potential diagnostic and prognostic applications.
Host Mouse
Immunogen Bcr686 thyroglobulin conjugate
Subclass IgG2a
Molecular Weight (kDa) 210
Myeloma Used P3X63Ag8
Recommended Growing Conditions DMEM + 5% FCS
Strain Balb/c
Research Area Cancer, Cell Signaling & Signal Transduction, Epigenetics & Nuclear Signalling

References: 3 entries

Dhut et al. 1990. Leukemia. 4(11):745-50. PMID: 2232885.

Dhut et al. 1988. Oncogene. 3(5):561-6. PMID: 3078961.

Walker et al. 1987. Nature. 329(6142):851-3. PMID: 3478595.


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