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Anti-XPA [5A2]

Info

Catalogue Number 151058
Applications ELISA WB
Antigen/Gene or Protein Targets XPA
Reactivity Human
Relevance XPA binds to the Replication Protein A (RPA) and is a core component of the nucleotide excision repair pathway. XPA is involved in one of the complementation groups of the heritable condition Xeroderma pigmentosum, where defects in nucleotide excision repair result in increased susceptibility to mutagens including UV.
Host Mouse
Immunogen HIS-tagged recombinant human XPA protein.
Subclass IgG1
Positive Control LS174T, MCF-7 cells or human tonsil
Molecular Weight (kDa) 40
Myeloma Used Sp2/0-Ag14
Recommended Growing Conditions DMEM + 5% FCS
Strain Balb/c
Research Area DNA Damage and Repair, Epigenetics & Nuclear Signalling

References: 6 entries

Wei et al. 2005. Cancer Epidemiol Biomarkers Prev. 14(8):1961-6. PMID: 16103444.

Expression of nucleotide excision repair proteins in lymphocytes as a marker of susceptibility to squamous cell carcinomas of the head and neck.

Europe PMC ID: 16103444

Welsh et al. 2004. Int J Cancer. 110(3):352-61. PMID: 15095299.

Reduced levels of XPA, ERCC1 and XPF DNA repair proteins in testis tumor cell lines.

Europe PMC ID: 15095299

Köberle et al. 1999. Curr Biol. 9(5):273-6. PMID: 10074455.

Defective repair of cisplatin-induced DNA damage caused by reduced XPA protein in testicular germ cell tumours.

Europe PMC ID: 10074455


Add a reference

References: 6 entries

Wei et al. 2005. Cancer Epidemiol Biomarkers Prev. 14(8):1961-6. PMID: 16103444.

Expression of nucleotide excision repair proteins in lymphocytes as a marker of susceptibility to squamous cell carcinomas of the head and neck.

Europe PMC ID: 16103444

Welsh et al. 2004. Int J Cancer. 110(3):352-61. PMID: 15095299.

Reduced levels of XPA, ERCC1 and XPF DNA repair proteins in testis tumor cell lines.

Europe PMC ID: 15095299

Köberle et al. 1999. Curr Biol. 9(5):273-6. PMID: 10074455.

Defective repair of cisplatin-induced DNA damage caused by reduced XPA protein in testicular germ cell tumours.

Europe PMC ID: 10074455


Add a reference

References: 6 entries

Wei et al. 2005. Cancer Epidemiol Biomarkers Prev. 14(8):1961-6. PMID: 16103444.

Expression of nucleotide excision repair proteins in lymphocytes as a marker of susceptibility to squamous cell carcinomas of the head and neck.

Welsh et al. 2004. Int J Cancer. 110(3):352-61. PMID: 15095299.

Reduced levels of XPA, ERCC1 and XPF DNA repair proteins in testis tumor cell lines.

Köberle et al. 1999. Curr Biol. 9(5):273-6. PMID: 10074455.

Defective repair of cisplatin-induced DNA damage caused by reduced XPA protein in testicular germ cell tumours.


Add a reference


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