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Anti-Macrophage marker [5/9]

Info

Catalogue Number 151057
Applications IHC
Antigen/Gene or Protein Targets Macrophage marker
Reactivity Human
Relevance Monoclonal antibody capable of detecting osteoclasts and macrophages.

Background and Research Application
Macrophages are comprised of many forms of mononuclear phagocytes found in tissues. Mononuclear phagocytes arise from hematopoietic stem cells in the bone marrow. Functions of macrophages include non-specific phagocytosis and pinocytosis, specific phagocytosis of opsonized microorganisms mediated by Fc receptors and complement receptors. They also assist with the killing of ingested microorganisms, digestion and presentation of antigens to T and B lymphocytes, and secretion of enzymes and regulatory molecules.

Antibody 5/9 may be used as a macrophage cell marker. The antigen is present in osteoclasts and 5/9 may be useful for the identification of osteoclasts in tissues relevant to developmental pathobiology.
Host Mouse
Immunogen A cell suspension containing osteoclasts from osteoclastomas.
Subclass IgG1
Myeloma Used P3X63Ag8.653
Recommended Growing Conditions DMEM + 5% FCS
Strain Balb/c
Notes Production Details
Purified using multi-step affinity chromatography with protein A.

Storage Conditions
Store at -20 degrees frozen. Avoid repeated freeze/thaw cycles.

Concentration
1mg/ml as standard
Research Area Cell Type or Organelle Marker, Immunology

References

There are 2 reference entries for this reagent.

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References: 2 entries

Horton et al. 1985. Cancer Res. 45(11 Pt 2):5663-9. PMID: 4053038.

Monoclonal antibodies to osteoclastomas (giant cell bone tumors): definition of osteoclast-specific cellular antigens.

Europe PMC ID: 4053038


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References: 2 entries

Horton et al. 1985. Cancer Res. 45(11 Pt 2):5663-9. PMID: 4053038.

Monoclonal antibodies to osteoclastomas (giant cell bone tumors): definition of osteoclast-specific cellular antigens.


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Inventor Information

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