Cat. #151057
Anti-Macrophage marker [5/9]
Cat. #: 151057
Sub-type: Primary antibody
Unit size: 100 ug
Availability: 3-4 weeks
Target: Macrophage marker
Class: Monoclonal
Application: IHC
Reactivity: Human
Host: Mouse
£300.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Mike Horton
Institute: Queen Mary University of London
Tool Details
*FOR RESEARCH USE ONLY
- Name: Anti-Macrophage marker [5/9]
- Clone: 0.555555555556
- Tool type ecom: Antibodies
- Tool sub type: Primary antibody
- Class: Monoclonal
- Conjugation: Unconjugated
- Strain: Balb/c
- Reactivity: Human
- Host: Mouse
- Application: IHC
- Description: Monoclonal antibody capable of detecting osteoclasts and macrophages.
- Immunogen: A cell suspension containing osteoclasts from osteoclastomas.
- Isotype: IgG1
- Myeloma used: P3X63Ag8.653
- Recommended controls: This antibody was used to detect S100A8/S100A9 in neutrophil extracts (Hogg et al., 1989) This antibody was used to detect S100A8/S100A9 in Human monocyte and neutrophil extracts (Edgeworth et al., 1991)
Target Details
- Target: Macrophage marker
- Tissue cell line specificity: This antibody was used to detect S100A8/S100A9 in neutrophil extracts (Hogg et al., 1989) This antibody was used to detect S100A8/S100A9 in Human monocyte and neutrophil extracts (Edgeworth et al., 1991)
- Target background: Macrophages are comprised of many forms of mononuclear phagocytes found in tissues. Mononuclear phagocytes arise from hematopoietic stem cells in the bone marrow. Functions of macrophages include non-specific phagocytosis and pinocytosis, specific phagocytosis of opsonized microorganisms mediated by Fc receptors and complement receptors. They also assist with the killing of ingested microorganisms, digestion and presentation of antigens to T and B lymphocytes, and secretion of enzymes and regulatory molecules. Antibody 5/9 may be used as a macrophage cell marker. The antigen is present in osteoclasts and 5/9 may be useful for the identification of osteoclasts in tissues relevant to developmental pathobiology.
Applications
- Application: IHC
Handling
- Format: Liquid
- Concentration: 1 mg/ml
- Unit size: 100 ug
- Storage buffer: PBS with 0.02% azide
- Storage conditions: Store at -20° C frozen. Avoid repeated freeze / thaw cycles
- Shipping conditions: Shipping at 4° C
References
- Horton et al. 1985. Cancer Res. 45(11 Pt 2):5663-9. PMID: 4053038.
- Monoclonal antibodies to osteoclastomas (giant cell bone tumors): definition of osteoclast-specific cellular antigens.
