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Anti-S100A8 & S100A9 [5.5]


Catalogue Number 151056
Antigen/Gene or Protein Targets S100A8 (MRP-8) & S100A9 (MRP-14)
Reactivity Human
Relevance S100A8 (MRP-8) and S100A9 (MRP-14) are cytosolic calcium-binding proteins of 8kDa and 14kDa that form a heterodimer. S100A8 and S100A9 are expressed in secretory and inflamed keratinocytes, peripheral blood monocytes, neutrophils and has been described in platelets, dendritic cells and some T cell types. Expression is lost on tissue maturation of monocytes to macrophages. S100A9 may be associated with monocyte and neutrophil activation and the accumulation of these cells in inflammatory sites.
Host Mouse
Immunogen Acute monocytic leukaemia cells.
Subclass IgG1
Positive Control This antibody was used to detect S100A8/S100A9 in neutrophil extracts (Hogg et al., 1989) This antibody was used to detect S100A8/S100A9 in Human monocyte and neutrophil extracts (Edgeworth et al., 1991)
Recommended Growing Conditions DMEM + 5% FCS
Research Area Cell Cycle, Epigenetics & Nuclear Signalling

References: 4 entries

Ryckman et al. 2003. Arthritis Rheum. 48(8):2310-20. PMID: 12905486.

Hessian et al. 2001. Eur J Biochem. 268(2):353-63. PMID: 11168370.

Edgeworth et al. 1991. J Biol Chem. 266(12):7706-13. PMID: 2019594.

Hogg et al. 1989. Eur J Immunol. 19(6):1053-61. PMID: 2666142.

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