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Anti-BCRABL [4C12]


Catalogue Number 151054
Applications IHC IF RIA
Antigen/Gene or Protein Targets BCRABL
Reactivity Human
Relevance The BCR gene is involved in the 9:22 translocation that generates the Philadelphia chromosome both in chronic myeloid leukemia (CML) and in a proportion of cases of acute lymphocytic leukemia (ALL). A 5' bcr sequence becomes fused to an abl sequence (including tyrosine kinase domain sequences) from chromosome 9 and results in the production of a chimaeric BCR-ABL protein with enhanced kinase activity. These antibodies may be useful for studies of the oncogene and have potential diagnostic and prognostic applications.
Host Mouse
Immunogen BCR-ABL peptide
Subclass IgG1
Myeloma Used P3X63Ag8.653
Recommended Growing Conditions DMEM + 5% FCS
Strain Balb/c
Notes Immunocytochemistry/Immunofluorescence 1:40-1:80
Research Area Cancer, Cell Signaling & Signal Transduction, Epigenetics & Nuclear Signalling

References: 3 entries

Dhut et al. 1990. Leukemia. 4(11):745-50. PMID: 2232885.

Dhut et al. 1988. Oncogene. 3(5):561-6. PMID: 3078961.

Walker et al. 1987. Nature. 329(6142):851-3. PMID: 3478595.

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