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Anti-ERCC1 [ERCC1 3H11]

Info

Catalogue Number 151050
Applications IF IP WB
Antigen/Gene or Protein Targets ERCC1
Reactivity Human
Relevance Nucleotide excision repair (NER) is a DNA repair pathway that removes lesions induced by a variety of agents such as UV irradiation. ERCC1 binds to XPF to form the heterodimer ERCC1-XPF, which is a DNA endonuclease that is essential for the dual incision step of NER (cleaves 5' of the DNA lesion). Some publications report that ERCC1 is elevated in cisplatin-resistant cells.
Host Mouse
Immunogen Full length HIS-tagged recombinant human ERCC1
Subclass IgG2a
Positive Control A431 cells or HeLa
Molecular Weight (kDa) 33-36
Myeloma Used Sp2/0-Ag14
Recommended Growing Conditions DMEM + 5% FCS
Strain Balb/c
Research Area Cancer, DNA Damage and Repair, Epigenetics & Nuclear Signalling

References: 3 entries

O'Dowd et al. 2012. PLoS Pathog. 8(11):e1003038. PMID: 23209410.

IF

Bhagwat et al. 2009. Cancer Res. 69(17):6831-8. PMID: 19723666.

Biggerstaff et al. 1993. EMBO J. 12(9):3685-92. PMID: 8253090.


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