Anti-ERCC1 [ERCC1 3H11]
Invented at Cancer Research UK London Research Institute: Lincoln's Inn Fields
- Datasheet
- References (6)
- Inventor Info
Info
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| Catalogue Number | 151050 |
| Applications | IF IP WB |
| Antigen/Gene or Protein Targets | ERCC1 |
| Reactivity | Human |
| Relevance | Nucleotide excision repair (NER) is a DNA repair pathway that removes lesions induced by a variety of agents such as UV irradiation. ERCC1 binds to XPF to form the heterodimer ERCC1-XPF, which is a DNA endonuclease that is essential for the dual incision step of NER (cleaves 5' of the DNA lesion). Some publications report that ERCC1 is elevated in cisplatin-resistant cells. |
| Host | Mouse |
| Immunogen | Full length HIS-tagged recombinant human ERCC1 |
| Positive Control | A431 cells or HeLa |
| Subclass | IgG2a |
| Molecular Weight (kDa) | 33-36 |
| Myeloma Used | Sp2/0-Ag14 |
| Recommended Growing Conditions | DMEM + 5% FCS |
| Strain | Balb/c |
| Research Area | Cancer, DNA Damage and Repair, Epigenetics & Nuclear Signalling |
References: 6 entries
HCMV-infected cells maintain efficient nucleotide excision repair of the viral genome while abrogating repair of the host genome.
Europe PMC ID: 23209410
O'Dowd et al. 2012. PLoS Pathog. 8(11):e1003038. PMID: 23209410.
IF
Bhagwat et al. 2009. Cancer Res. 69(17):6831-8. PMID: 19723666.
Immunodetection of DNA repair endonuclease ERCC1-XPF in human tissue.
Europe PMC ID: 19723666
Biggerstaff et al. 1993. EMBO J. 12(9):3685-92. PMID: 8253090.
Co-correction of the ERCC1, ERCC4 and xeroderma pigmentosum group F DNA repair defects in vitro.
Europe PMC ID: 8253090
Add a reference
References: 6 entries
HCMV-infected cells maintain efficient nucleotide excision repair of the viral genome while abrogating repair of the host genome.
O'Dowd et al. 2012. PLoS Pathog. 8(11):e1003038. PMID: 23209410.
IF
Bhagwat et al. 2009. Cancer Res. 69(17):6831-8. PMID: 19723666.
Immunodetection of DNA repair endonuclease ERCC1-XPF in human tissue.
Biggerstaff et al. 1993. EMBO J. 12(9):3685-92. PMID: 8253090.
Co-correction of the ERCC1, ERCC4 and xeroderma pigmentosum group F DNA repair defects in vitro.
Add a reference
