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Catalogue Number 151048
Applications FACS IHC IF IP Fn
Antigen/Gene or Protein Targets Integrin alpha L subunit (CD11a, LFA-1 alpha)
Synonyms Integrin Subunit Alpha L; Leukocyte Function-Associated Molecule 1 Alpha Chain; CD11 Antigen-Like Family Member A; Antigen CD11A (P180); LFA-1A; CD11A; Antigen CD11A (P180); Lymphocyte Function-Associated Antigen 1; Lymphocyte Function-Associated Antigen 1; Alpha Polypeptide; Integrin Gene Promoter; Alpha Polypeptide; Integrin Alpha L; CD11a Antigen; LFA-1; LFA1A
Reactivity Human
Relevance Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Integrin alpha L (CD11a) is expressed on all human leucocytes, with increased expression on memory T cells. This integrin has a major role in the migration of both normal and leukaemic leukocytes.
Host Mouse
Immunogen Fibronectin purified monocytes.
Subclass IgG2a
Molecular Weight (kDa) 175
Myeloma Used Sp2/0-Ag14
Recommended Growing Conditions DMEM + 5% FCS
Strain Balb/c
Notes Blocking/Neutralizing 50-200 molar excess

Flow Cytometry <= 1 ug/10^6 cells

Immunohistochemistry 1:10-1:2000

Immunohistochemistry-Frozen 1:10-1:2000

Immunoprecipitation 1:10-1:500
Research Area Adhesion

References: 14 entries

Iglesia et al. 2017. Stem Cell Res Ther. 8(1):76. PMID: 28412969.

Engagement of cellular prion protein with the co-chaperone Hsp70/90 organizing protein regulates the proliferation of glioblastoma stem-like cells.

Europe PMC ID: 28412969

Pathak et al. 2012. J Biol Chem. 287(17):13731-42. PMID: 22396536.

Activated apoptotic cells induce dendritic cell maturation via engagement of Toll-like receptor 4 (TLR4), dendritic cell-specific intercellular adhesion molecule 3 (ICAM-3)-grabbing nonintegrin (DC-SIGN), and β2 integrins.

Europe PMC ID: 22396536

Porter et al. 2009. FASEB J. 23(2):492-502. PMID: 18842965.

Epithelial ICAM-1 and ICAM-2 regulate the egression of human T cells across the bronchial epithelium.

Europe PMC ID: 18842965

McDowall et al. 2003. J Clin Invest. 111(1):51-60. PMID: 12511588.

A novel form of integrin dysfunction involving beta1, beta2, and beta3 integrins.

Europe PMC ID: 12511588

Stanley et al. 2000. Biochem J. 351(Pt 1):79-86. PMID: 10998349.

The second domain of intercellular adhesion molecule-1 (ICAM-1) maintains the structural integrity of the leucocyte function-associated antigen-1 (LFA-1) ligand-binding site in the first domain.

Europe PMC ID: 10998349

Dransfield et al. 1989. EMBO J. 8(12):3759-65. PMID: 2479549.

Regulated expression of Mg2+ binding epitope on leukocyte integrin alpha subunits.

Europe PMC ID: 2479549

Hogg et al. 1986. Eur J Immunol. 16(3):240-8. PMID: 3456894.

The p150,95 molecule is a marker of human mononuclear phagocytes: comparison with expression of class II molecules.

Europe PMC ID: 3456894


Add a reference

References: 14 entries

Iglesia et al. 2017. Stem Cell Res Ther. 8(1):76. PMID: 28412969.

Engagement of cellular prion protein with the co-chaperone Hsp70/90 organizing protein regulates the proliferation of glioblastoma stem-like cells.

Europe PMC ID: 28412969

Pathak et al. 2012. J Biol Chem. 287(17):13731-42. PMID: 22396536.

Activated apoptotic cells induce dendritic cell maturation via engagement of Toll-like receptor 4 (TLR4), dendritic cell-specific intercellular adhesion molecule 3 (ICAM-3)-grabbing nonintegrin (DC-SIGN), and β2 integrins.

Europe PMC ID: 22396536

Porter et al. 2009. FASEB J. 23(2):492-502. PMID: 18842965.

Epithelial ICAM-1 and ICAM-2 regulate the egression of human T cells across the bronchial epithelium.

Europe PMC ID: 18842965

McDowall et al. 2003. J Clin Invest. 111(1):51-60. PMID: 12511588.

A novel form of integrin dysfunction involving beta1, beta2, and beta3 integrins.

Europe PMC ID: 12511588

Stanley et al. 2000. Biochem J. 351(Pt 1):79-86. PMID: 10998349.

The second domain of intercellular adhesion molecule-1 (ICAM-1) maintains the structural integrity of the leucocyte function-associated antigen-1 (LFA-1) ligand-binding site in the first domain.

Europe PMC ID: 10998349

Dransfield et al. 1989. EMBO J. 8(12):3759-65. PMID: 2479549.

Regulated expression of Mg2+ binding epitope on leukocyte integrin alpha subunits.

Europe PMC ID: 2479549

Hogg et al. 1986. Eur J Immunol. 16(3):240-8. PMID: 3456894.

The p150,95 molecule is a marker of human mononuclear phagocytes: comparison with expression of class II molecules.

Europe PMC ID: 3456894


Add a reference

References: 14 entries

Iglesia et al. 2017. Stem Cell Res Ther. 8(1):76. PMID: 28412969.

Engagement of cellular prion protein with the co-chaperone Hsp70/90 organizing protein regulates the proliferation of glioblastoma stem-like cells.

Pathak et al. 2012. J Biol Chem. 287(17):13731-42. PMID: 22396536.

Activated apoptotic cells induce dendritic cell maturation via engagement of Toll-like receptor 4 (TLR4), dendritic cell-specific intercellular adhesion molecule 3 (ICAM-3)-grabbing nonintegrin (DC-SIGN), and β2 integrins.

Porter et al. 2009. FASEB J. 23(2):492-502. PMID: 18842965.

Epithelial ICAM-1 and ICAM-2 regulate the egression of human T cells across the bronchial epithelium.

McDowall et al. 2003. J Clin Invest. 111(1):51-60. PMID: 12511588.

A novel form of integrin dysfunction involving beta1, beta2, and beta3 integrins.

Stanley et al. 2000. Biochem J. 351(Pt 1):79-86. PMID: 10998349.

The second domain of intercellular adhesion molecule-1 (ICAM-1) maintains the structural integrity of the leucocyte function-associated antigen-1 (LFA-1) ligand-binding site in the first domain.

Dransfield et al. 1989. EMBO J. 8(12):3759-65. PMID: 2479549.

Regulated expression of Mg2+ binding epitope on leukocyte integrin alpha subunits.

Hogg et al. 1986. Eur J Immunol. 16(3):240-8. PMID: 3456894.

The p150,95 molecule is a marker of human mononuclear phagocytes: comparison with expression of class II molecules.


Add a reference


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