Anti-CD11a (Integrin aL) [38]
Invented by Prof Nancy Hogg from Cancer Research UK London Research Institute: Lincoln's Inn Fields
Invented at Cancer Research UK London Research Institute: Lincoln's Inn Fields
- Datasheet
- References (14)
- Inventor Info
Info
| Catalogue Number | 151048 |
| Applications | FACS IHC IF IP Fn |
| Antigen/Gene or Protein Targets | Integrin alpha L subunit (CD11a, LFA-1 alpha) |
| Synonyms | Integrin Subunit Alpha L; Leukocyte Function-Associated Molecule 1 Alpha Chain; CD11 Antigen-Like Family Member A; Antigen CD11A (P180); LFA-1A; CD11A; Antigen CD11A (P180); Lymphocyte Function-Associated Antigen 1; Lymphocyte Function-Associated Antigen 1; Alpha Polypeptide; Integrin Gene Promoter; Alpha Polypeptide; Integrin Alpha L; CD11a Antigen; LFA-1; LFA1A |
| Reactivity | Human |
| Relevance | Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Integrin alpha L (CD11a) is expressed on all human leucocytes, with increased expression on memory T cells. This integrin has a major role in the migration of both normal and leukaemic leukocytes. |
| Host | Mouse |
| Immunogen | Fibronectin purified monocytes. |
| Subclass | IgG2a |
| Molecular Weight (kDa) | 175 |
| Myeloma Used | Sp2/0-Ag14 |
| Recommended Growing Conditions | DMEM + 5% FCS |
| Strain | Balb/c |
| Notes |
Blocking/Neutralizing 50-200 molar excess Flow Cytometry <= 1 ug/10^6 cells Immunohistochemistry 1:10-1:2000 Immunohistochemistry-Frozen 1:10-1:2000 Immunoprecipitation 1:10-1:500 |
| Research Area | Adhesion |
References: 14 entries
Iglesia et al. 2017. Stem Cell Res Ther. 8(1):76. PMID: 28412969.
Engagement of cellular prion protein with the co-chaperone Hsp70/90 organizing protein regulates the proliferation of glioblastoma stem-like cells.
Europe PMC ID: 28412969
Pathak et al. 2012. J Biol Chem. 287(17):13731-42. PMID: 22396536.
Activated apoptotic cells induce dendritic cell maturation via engagement of Toll-like receptor 4 (TLR4), dendritic cell-specific intercellular adhesion molecule 3 (ICAM-3)-grabbing nonintegrin (DC-SIGN), and β2 integrins.
Europe PMC ID: 22396536
Porter et al. 2009. FASEB J. 23(2):492-502. PMID: 18842965.
Epithelial ICAM-1 and ICAM-2 regulate the egression of human T cells across the bronchial epithelium.
Europe PMC ID: 18842965
McDowall et al. 2003. J Clin Invest. 111(1):51-60. PMID: 12511588.
A novel form of integrin dysfunction involving beta1, beta2, and beta3 integrins.
Europe PMC ID: 12511588
Stanley et al. 2000. Biochem J. 351(Pt 1):79-86. PMID: 10998349.
The second domain of intercellular adhesion molecule-1 (ICAM-1) maintains the structural integrity of the leucocyte function-associated antigen-1 (LFA-1) ligand-binding site in the first domain.
Europe PMC ID: 10998349
Dransfield et al. 1989. EMBO J. 8(12):3759-65. PMID: 2479549.
Regulated expression of Mg2+ binding epitope on leukocyte integrin alpha subunits.
Europe PMC ID: 2479549
Hogg et al. 1986. Eur J Immunol. 16(3):240-8. PMID: 3456894.
The p150,95 molecule is a marker of human mononuclear phagocytes: comparison with expression of class II molecules.
Europe PMC ID: 3456894
Add a reference
References: 14 entries
Iglesia et al. 2017. Stem Cell Res Ther. 8(1):76. PMID: 28412969.
Engagement of cellular prion protein with the co-chaperone Hsp70/90 organizing protein regulates the proliferation of glioblastoma stem-like cells.
Pathak et al. 2012. J Biol Chem. 287(17):13731-42. PMID: 22396536.
Activated apoptotic cells induce dendritic cell maturation via engagement of Toll-like receptor 4 (TLR4), dendritic cell-specific intercellular adhesion molecule 3 (ICAM-3)-grabbing nonintegrin (DC-SIGN), and β2 integrins.
Porter et al. 2009. FASEB J. 23(2):492-502. PMID: 18842965.
Epithelial ICAM-1 and ICAM-2 regulate the egression of human T cells across the bronchial epithelium.
McDowall et al. 2003. J Clin Invest. 111(1):51-60. PMID: 12511588.
A novel form of integrin dysfunction involving beta1, beta2, and beta3 integrins.
Stanley et al. 2000. Biochem J. 351(Pt 1):79-86. PMID: 10998349.
The second domain of intercellular adhesion molecule-1 (ICAM-1) maintains the structural integrity of the leucocyte function-associated antigen-1 (LFA-1) ligand-binding site in the first domain.
Dransfield et al. 1989. EMBO J. 8(12):3759-65. PMID: 2479549.
Regulated expression of Mg2+ binding epitope on leukocyte integrin alpha subunits.
Hogg et al. 1986. Eur J Immunol. 16(3):240-8. PMID: 3456894.
The p150,95 molecule is a marker of human mononuclear phagocytes: comparison with expression of class II molecules.
Add a reference
