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Anti-CD45R [351C5]


Catalogue Number 151047
Applications FACS IHC IF IP WB
Antigen/Gene or Protein Targets Protein tyrosine phosphatase, receptor type, C (PTPRC, CD45R)
Synonyms Protein Tyrosine Phosphatase; Receptor Type C; CD45 Antigen; CD45; L-CA; T200; Protein Tyrosine Phosphatase; Receptor Type; C Polypeptide; T200 Leukocyte Common Antigen; T200 Glycoprotein; EC; GP180; CD45R; B220; LCA; LY5
Reactivity Human
Relevance PTPRC (CD45) is a transmembrane tyrosine phosphatase that is present on all leukocytes. PTPRC regulates the threshold of T cell antigen receptor (TCR) signaling through dephosphorylation of protein tyrosine kinases (e.g. Lck and Fyn). CD45R and CD45RO are two of multiple PTPRC isoforms generated by alternative splicing. CD45R is found on B lymphocyte and T lymphocyte subsets. CD45RO is present on 50% of T cells, most granulocytes and monocytes and most mature T cell tumours. 351C5 may be used in the typing of leukaemias and lymphomas and in studies of functional subsets of B and T cells.
Host Mouse
Immunogen Raji cells
Subclass IgM
Recommended Growing Conditions DMEM + 5% FCS
Research Area Cancer, Cell Type or Organelle Marker, Cell Signaling & Signal Transduction, Immunology, Stem Cell Biology

References: 3 entries

Leitenberg et al. 1996. J Exp Med. 183(1):249-59. PMID: 8551228.

Trowbridge et al. 1994. Annu Rev Immunol. 12:85-116. PMID: 8011300.

Murray et al. 1985. Clin Exp Immunol. 59(2):315-26. PMID: 3872187.

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