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Catalogue Number 151044
Applications FACS IHC IF IP Fn
Antigen/Gene or Protein Targets Integrin alpha X (CD11c; gp150/95 a subunit)
Reactivity Human
Relevance Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin alpha X is found on hairy cell leukaemias, malignant histiocytes, on tissue macrophages, monocytes, activated neutrophils and some T-cell clones.
Host Mouse
Immunogen Rheumatoid synovial fluid cells and fibronectin purified human monocytes
Subclass IgG1
Positive Control Peripheral blood monocytes (PBMCs) (FACS), Uterine tissue sections (IHC)
Molecular Weight (kDa) 150
Myeloma Used Sp2/0-Ag14
Recommended Growing Conditions DMEM + 5% FCS
Strain Balb/c
Notes Shown to inhibit adhesion in Jawhara et al., 2012.

For FACS: 1ug per 1x10^6 cells
Research Area Adhesion, Cell Signaling & Signal Transduction, Immunology, Stem Cell Biology

References: 23 entries

Locci et al. 2016. Nat Immunol. :. PMID: 27376469.

IF

Activin A programs the differentiation of human TFH cells.

Europe PMC ID: 27376469

Göbel et al. 2016. Nat Commun. 7:11626. PMID: 27188843.

FACS IHC

Blood coagulation factor XII drives adaptive immunity during neuroinflammation via CD87-mediated modulation of dendritic cells.

Europe PMC ID: 27188843

Expression of death receptor 3 on peripheral blood mononuclear cells differes in adult IBD patients and children with newly diagnosed IBD.

Europe PMC ID: 27001939

Dendritic Cell-Secreted Cytotoxic T-Lymphocyte-Associated Protein-4 Regulates the T-cell Response by Downmodulating Bystander Surface B7.

Europe PMC ID: 26979751

Slebioda et al. 2016. Cytometry B Clin Cytom. :. PMID: 27001939.

FACS

Halpert et al. 2016. Stem Cells Dev. :. PMID: 26979751.

Alginate microsphere compositions dictate different mechanisms of complement activation with consequences for cytokine release and leukocyte activation.

Europe PMC ID: 26993426

Ørning et al. 2016. J Control Release. :. PMID: 26993426.

Swindle et al. 2015. Immunology. 146(3):470-85. PMID: 26288256.

Increased proportions of dendritic cells and recovery of IFNγ responses in HIV/HCV co-infected patients receiving ART.

Europe PMC ID: 26455474

Saraswati et al. 2015. Hum Immunol. :. PMID: 26455474.

Interferon-γ enhances both the anti-bacterial and the pro-inflammatory response of human mast cells to Staphylococcus aureus.

Europe PMC ID: 26288256

Petvises et al. 2015. Cell Mol Immunol. :. PMID: 25891217.

Delineation of a novel dendritic-like subset in human spleen.

Europe PMC ID: 25891217

Nausch et al. 2015. PLoS Negl Trop Dis. 9(3):e0003627. PMID: 25799270.

Group 2 innate lymphoid cell proportions are diminished in young helminth infected children and restored by curative anti-helminthic treatment.

Europe PMC ID: 25799270

Jawhara et al. 2012. J Immunol. 189(5):2468-77. PMID: 22844116.

Integrin αXβ₂ is a leukocyte receptor for Candida albicans and is essential for protection against fungal infections.

Europe PMC ID: 22844116

McMichael AJ et al. (Ed) 1997. Leucocyte Typing III. ISBN 13 9780192615527

Hogg et al. 1986. Eur J Immunol. 16(3):240-8. PMID: 3456894.

The p150,95 molecule is a marker of human mononuclear phagocytes: comparison with expression of class II molecules.

Europe PMC ID: 3456894


Add a reference

References: 23 entries

Locci et al. 2016. Nat Immunol. :. PMID: 27376469.

IF

Activin A programs the differentiation of human TFH cells.

Europe PMC ID: 27376469

Göbel et al. 2016. Nat Commun. 7:11626. PMID: 27188843.

FACS IHC

Blood coagulation factor XII drives adaptive immunity during neuroinflammation via CD87-mediated modulation of dendritic cells.

Europe PMC ID: 27188843

Expression of death receptor 3 on peripheral blood mononuclear cells differes in adult IBD patients and children with newly diagnosed IBD.

Europe PMC ID: 27001939

Dendritic Cell-Secreted Cytotoxic T-Lymphocyte-Associated Protein-4 Regulates the T-cell Response by Downmodulating Bystander Surface B7.

Europe PMC ID: 26979751

Slebioda et al. 2016. Cytometry B Clin Cytom. :. PMID: 27001939.

FACS

Halpert et al. 2016. Stem Cells Dev. :. PMID: 26979751.

Alginate microsphere compositions dictate different mechanisms of complement activation with consequences for cytokine release and leukocyte activation.

Europe PMC ID: 26993426

Ørning et al. 2016. J Control Release. :. PMID: 26993426.

Swindle et al. 2015. Immunology. 146(3):470-85. PMID: 26288256.

Increased proportions of dendritic cells and recovery of IFNγ responses in HIV/HCV co-infected patients receiving ART.

Europe PMC ID: 26455474

Saraswati et al. 2015. Hum Immunol. :. PMID: 26455474.

Interferon-γ enhances both the anti-bacterial and the pro-inflammatory response of human mast cells to Staphylococcus aureus.

Europe PMC ID: 26288256

Petvises et al. 2015. Cell Mol Immunol. :. PMID: 25891217.

Delineation of a novel dendritic-like subset in human spleen.

Europe PMC ID: 25891217

Nausch et al. 2015. PLoS Negl Trop Dis. 9(3):e0003627. PMID: 25799270.

Group 2 innate lymphoid cell proportions are diminished in young helminth infected children and restored by curative anti-helminthic treatment.

Europe PMC ID: 25799270

Jawhara et al. 2012. J Immunol. 189(5):2468-77. PMID: 22844116.

Integrin αXβ₂ is a leukocyte receptor for Candida albicans and is essential for protection against fungal infections.

Europe PMC ID: 22844116

McMichael AJ et al. (Ed) 1997. Leucocyte Typing III. ISBN 13 9780192615527

Hogg et al. 1986. Eur J Immunol. 16(3):240-8. PMID: 3456894.

The p150,95 molecule is a marker of human mononuclear phagocytes: comparison with expression of class II molecules.

Europe PMC ID: 3456894


Add a reference

References: 23 entries

Locci et al. 2016. Nat Immunol. :. PMID: 27376469.

IF

Activin A programs the differentiation of human TFH cells.

Göbel et al. 2016. Nat Commun. 7:11626. PMID: 27188843.

FACS IHC

Blood coagulation factor XII drives adaptive immunity during neuroinflammation via CD87-mediated modulation of dendritic cells.

Expression of death receptor 3 on peripheral blood mononuclear cells differes in adult IBD patients and children with newly diagnosed IBD.

Dendritic Cell-Secreted Cytotoxic T-Lymphocyte-Associated Protein-4 Regulates the T-cell Response by Downmodulating Bystander Surface B7.

Slebioda et al. 2016. Cytometry B Clin Cytom. :. PMID: 27001939.

FACS

Halpert et al. 2016. Stem Cells Dev. :. PMID: 26979751.

Alginate microsphere compositions dictate different mechanisms of complement activation with consequences for cytokine release and leukocyte activation.

Ørning et al. 2016. J Control Release. :. PMID: 26993426.

Swindle et al. 2015. Immunology. 146(3):470-85. PMID: 26288256.

Increased proportions of dendritic cells and recovery of IFNγ responses in HIV/HCV co-infected patients receiving ART.

Saraswati et al. 2015. Hum Immunol. :. PMID: 26455474.

Interferon-γ enhances both the anti-bacterial and the pro-inflammatory response of human mast cells to Staphylococcus aureus.

Petvises et al. 2015. Cell Mol Immunol. :. PMID: 25891217.

Delineation of a novel dendritic-like subset in human spleen.

Nausch et al. 2015. PLoS Negl Trop Dis. 9(3):e0003627. PMID: 25799270.

Group 2 innate lymphoid cell proportions are diminished in young helminth infected children and restored by curative anti-helminthic treatment.

Jawhara et al. 2012. J Immunol. 189(5):2468-77. PMID: 22844116.

Integrin αXβ₂ is a leukocyte receptor for Candida albicans and is essential for protection against fungal infections.

McMichael AJ et al. (Ed) 1997. Leucocyte Typing III. ISBN 13 9780192615527

Hogg et al. 1986. Eur J Immunol. 16(3):240-8. PMID: 3456894.

The p150,95 molecule is a marker of human mononuclear phagocytes: comparison with expression of class II molecules.


Add a reference


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