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Anti-Integrin aX [3.9]


Catalogue Number 151044
Applications FACS IHC IF IP Fn
Antigen/Gene or Protein Targets Integrin alpha X (CD11c; gp150/95 a subunit)
Reactivity Human
Relevance Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin alpha X is found on hairy cell leukaemias, malignant histiocytes, on tissue macrophages, monocytes, activated neutrophils and some T-cell clones.
Host Mouse
Immunogen Rheumatoid synovial fluid cells and fibronectin purified human monocytes
Subclass IgG1
Positive Control Peripheral blood monocytes (PBMCs) (FACS), Uterine tissue sections (IHC)
Molecular Weight (kDa) 150
Myeloma Used Sp2/0-Ag14
Recommended Growing Conditions DMEM + 5% FCS
Strain Balb/c
Notes Shown to inhibit adhesion in Jawhara et al., 2012.

For FACS: 1ug per 1x10^6 cells
Research Area Adhesion, Cell Signaling & Signal Transduction, Immunology, Stem Cell Biology

References: 12 entries

Locci et al. 2016. Nat Immunol. :. PMID: 27376469.


Göbel et al. 2016. Nat Commun. 7:11626. PMID: 27188843.


Slebioda et al. 2016. Cytometry B Clin Cytom. :. PMID: 27001939.


Halpert et al. 2016. Stem Cells Dev. :. PMID: 26979751.

Ørning et al. 2016. J Control Release. :. PMID: 26993426.

Swindle et al. 2015. Immunology. 146(3):470-85. PMID: 26288256.

Saraswati et al. 2015. Hum Immunol. :. PMID: 26455474.

Petvises et al. 2015. Cell Mol Immunol. :. PMID: 25891217.

Nausch et al. 2015. PLoS Negl Trop Dis. 9(3):e0003627. PMID: 25799270.

Jawhara et al. 2012. J Immunol. 189(5):2468-77. PMID: 22844116.

McMichael AJ et al. (Ed) 1997. Leucocyte Typing III. ISBN 13 9780192615527

Hogg et al. 1986. Eur J Immunol. 16(3):240-8. PMID: 3456894.

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