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Catalogue Number 151040
Applications FACS IHC IF IP RIA WB
Antigen/Gene or Protein Targets Activation epitope on integrin beta 2(CD18) subunit
Synonyms Integrin Subunit Alpha L; Leukocyte Function-Associated Molecule 1 Alpha Chain; CD11 Antigen-Like Family Member A; Antigen CD11A (P180); LFA-1A; CD11A; Antigen CD11A (P180); Lymphocyte Function-Associated Antigen 1; Lymphocyte Function-Associated Antigen 1; Alpha Polypeptide; Integrin Gene Promoter; Alpha Polypeptide; Integrin Alpha L; CD11a Antigen; LFA-1; LFA1A
Reactivity Human
Relevance Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Integrin beta2 (CD18) associates with integrin alpha L (CD11a) to form the leukocyte function-associated antigen-1 (LFA-1), integrin alpha M (CD11b) to form Complement Receptor 3 (CR3), integrin alpha X (CD11c) to form Complement Receptor 4 (CR4) and with CD11d to form p150,95. Each integrin receptor can bind various Intercellular adhesion molecules (ICAMs) and matrix molecules. Clone 24 may be used as a reporter of the activation state of the CD11/CD18 integrins and can also be induced following exposure with Mg2+ or Mn2+.
Host Mouse
Immunogen Fibronectin-purified human monocytes .
Subclass IgG1
Positive Control Tonsil
Molecular Weight (kDa) 95 & 180
Myeloma Used Sp2/0-Ag14
Recommended Growing Conditions E4 + 10% FCS
Strain Balb/c
Notes CD18: 95 kDa, CD11: 180kDa
Research Area Adhesion

References: 10 entries

Chen et al. 2010. Proc Natl Acad Sci U S A. 107(33):14727-32. PMID: 20679211.

Requirement of open headpiece conformation for activation of leukocyte integrin alphaXbeta2.

Europe PMC ID: 20679211

Stanley et al. 2008. EMBO J. 27(1):62-75. PMID: 18079697.

IF WB

Intermediate-affinity LFA-1 binds alpha-actinin-1 to control migration at the leading edge of the T cell.

Europe PMC ID: 18079697

Smith et al. 2005. J Cell Biol. 170(1):141-51. PMID: 15983060.

A talin-dependent LFA-1 focal zone is formed by rapidly migrating T lymphocytes.

Europe PMC ID: 15983060

McDowall et al. 2003. J Clin Invest. 111(1):51-60. PMID: 12511588.

A novel form of integrin dysfunction involving beta1, beta2, and beta3 integrins.

Europe PMC ID: 12511588

Hogg et al. 1985. Cell Immunol. 92(2):247-53. PMID: 2581704.

An anti-human monocyte/macrophage monoclonal antibody, reacting most strongly with macrophages in lymphoid tissue.

Europe PMC ID: 2581704


Add a reference

References: 10 entries

Chen et al. 2010. Proc Natl Acad Sci U S A. 107(33):14727-32. PMID: 20679211.

Requirement of open headpiece conformation for activation of leukocyte integrin alphaXbeta2.

Europe PMC ID: 20679211

Stanley et al. 2008. EMBO J. 27(1):62-75. PMID: 18079697.

IF WB

Intermediate-affinity LFA-1 binds alpha-actinin-1 to control migration at the leading edge of the T cell.

Europe PMC ID: 18079697

Smith et al. 2005. J Cell Biol. 170(1):141-51. PMID: 15983060.

A talin-dependent LFA-1 focal zone is formed by rapidly migrating T lymphocytes.

Europe PMC ID: 15983060

McDowall et al. 2003. J Clin Invest. 111(1):51-60. PMID: 12511588.

A novel form of integrin dysfunction involving beta1, beta2, and beta3 integrins.

Europe PMC ID: 12511588

Hogg et al. 1985. Cell Immunol. 92(2):247-53. PMID: 2581704.

An anti-human monocyte/macrophage monoclonal antibody, reacting most strongly with macrophages in lymphoid tissue.

Europe PMC ID: 2581704


Add a reference

References: 10 entries

Chen et al. 2010. Proc Natl Acad Sci U S A. 107(33):14727-32. PMID: 20679211.

Requirement of open headpiece conformation for activation of leukocyte integrin alphaXbeta2.

Stanley et al. 2008. EMBO J. 27(1):62-75. PMID: 18079697.

IF WB

Intermediate-affinity LFA-1 binds alpha-actinin-1 to control migration at the leading edge of the T cell.

Smith et al. 2005. J Cell Biol. 170(1):141-51. PMID: 15983060.

A talin-dependent LFA-1 focal zone is formed by rapidly migrating T lymphocytes.

McDowall et al. 2003. J Clin Invest. 111(1):51-60. PMID: 12511588.

A novel form of integrin dysfunction involving beta1, beta2, and beta3 integrins.

Hogg et al. 1985. Cell Immunol. 92(2):247-53. PMID: 2581704.

An anti-human monocyte/macrophage monoclonal antibody, reacting most strongly with macrophages in lymphoid tissue.


Add a reference


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