Anti-CD11 & CD18 [24]
Invented by Prof Nancy Hogg from Cancer Research UK London Research Institute: Lincoln's Inn Fields
Invented at Cancer Research UK London Research Institute: Lincoln's Inn Fields
- Datasheet
- References (10)
- Inventor Info
Info
| Catalogue Number | 151040 |
| Applications | FACS IHC IF IP RIA WB |
| Antigen/Gene or Protein Targets | Activation epitope on integrin beta 2(CD18) subunit |
| Synonyms | Integrin Subunit Alpha L; Leukocyte Function-Associated Molecule 1 Alpha Chain; CD11 Antigen-Like Family Member A; Antigen CD11A (P180); LFA-1A; CD11A; Antigen CD11A (P180); Lymphocyte Function-Associated Antigen 1; Lymphocyte Function-Associated Antigen 1; Alpha Polypeptide; Integrin Gene Promoter; Alpha Polypeptide; Integrin Alpha L; CD11a Antigen; LFA-1; LFA1A |
| Reactivity | Human |
| Relevance | Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Integrin beta2 (CD18) associates with integrin alpha L (CD11a) to form the leukocyte function-associated antigen-1 (LFA-1), integrin alpha M (CD11b) to form Complement Receptor 3 (CR3), integrin alpha X (CD11c) to form Complement Receptor 4 (CR4) and with CD11d to form p150,95. Each integrin receptor can bind various Intercellular adhesion molecules (ICAMs) and matrix molecules. Clone 24 may be used as a reporter of the activation state of the CD11/CD18 integrins and can also be induced following exposure with Mg2+ or Mn2+. |
| Host | Mouse |
| Immunogen | Fibronectin-purified human monocytes . |
| Positive Control | Tonsil |
| Subclass | IgG1 |
| Molecular Weight (kDa) | 95 & 180 |
| Myeloma Used | Sp2/0-Ag14 |
| Recommended Growing Conditions | E4 + 10% FCS |
| Strain | Balb/c |
| Notes | CD18: 95 kDa, CD11: 180kDa |
| Research Area | Adhesion |
References: 10 entries
Drewry et al. 2019. Nat Microbiol. 4(11):1951-1963. PMID: 31332383.
Chen et al. 2019. Nanoscale. 11(12):5377-5394. PMID: 30849160.
Yuan et al. 2018. Eur J Cardiothorac Surg. 53(2):400-408. PMID: 28950359.
Laufer et al. 2018. Front Immunol. 9:3115. PMID: 30692994.
Manwani et al. 2015. Am J Hematol. 90(5):381-5. PMID: 25616042.
Chen et al. 2010. Proc Natl Acad Sci U S A. 107(33):14727-32. PMID: 20679211.
Stanley et al. 2008. EMBO J. 27(1):62-75. PMID: 18079697.
IF WB
Smith et al. 2005. J Cell Biol. 170(1):141-51. PMID: 15983060.
McDowall et al. 2003. J Clin Invest. 111(1):51-60. PMID: 12511588.
Hogg et al. 1985. Cell Immunol. 92(2):247-53. PMID: 2581704.
Add a reference
References: 10 entries
Drewry et al. 2019. Nat Microbiol. 4(11):1951-1963. PMID: 31332383.
Chen et al. 2019. Nanoscale. 11(12):5377-5394. PMID: 30849160.
Yuan et al. 2018. Eur J Cardiothorac Surg. 53(2):400-408. PMID: 28950359.
Laufer et al. 2018. Front Immunol. 9:3115. PMID: 30692994.
Manwani et al. 2015. Am J Hematol. 90(5):381-5. PMID: 25616042.
Chen et al. 2010. Proc Natl Acad Sci U S A. 107(33):14727-32. PMID: 20679211.
Stanley et al. 2008. EMBO J. 27(1):62-75. PMID: 18079697.
IF WB
Smith et al. 2005. J Cell Biol. 170(1):141-51. PMID: 15983060.
McDowall et al. 2003. J Clin Invest. 111(1):51-60. PMID: 12511588.
Hogg et al. 1985. Cell Immunol. 92(2):247-53. PMID: 2581704.
Add a reference
