Log in Register

Anti-Integrin aVb3 [23C6]


Catalogue Number 151039
Applications FACS IHC IP Fn
Antigen/Gene or Protein Targets Integrin alpha V ß3 (CD51/61; Osteoclast Functional Antigen)
Reactivity Human
Relevance Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin alpha V associates with integrin beta3 to form the osteoclast functional antigen (vitronectin receptor). Integrin alpha V is found in osteoclasts, placenta, melanoma cell lines and some epithelial cell lines. Expression of integrin alpha V increases with melanoma progression. 23C6 may be useful for bone resorption modulation, osteoclast identification, receptor purification, malignant melanoma identification and treatment.
Host Mouse
Immunogen A cell suspension containing osteoclasts from osteoclastomas.
Subclass IgG1
Positive Control Tonsil
Molecular Weight (kDa) 125/124, 150
Myeloma Used P3X63Ag8.653
Recommended Growing Conditions DMEM + 5% FCS
Strain Balb/c
Notes 125/124 kDa (reduced), 150kDa (non-reduced)
Research Area Adhesion, Cancer, Cardiovascular

References: 5 entries

Chetty et al. 2010. Int J Cancer. 127(5):1081-95. PMID: 20027628.


Martino et al. 2009. Biomaterials. 30(6):1089-97. PMID: 19027948.

Zhou et al. 2006. J Exp Med. 203(4):1067-80. PMID: 16606672.

Marshall et al. 1995. J Cell Sci. 108 ( Pt 3):1227-38. PMID: 7542669.

Horton et al. 1985. Cancer Res. 45(11 Pt 2):5663-9. PMID: 4053038.

Add a reference

This reagent does not have any reviews at the moment.