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Anti-Integrin aVb3 [23C6]

Info

Catalogue Number 151039
Applications FACS IHC IP Fn
Antigen/Gene or Protein Targets Integrin alpha V ß3 (CD51/61; Osteoclast Functional Antigen)
Reactivity Human
Relevance Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin alpha V associates with integrin beta3 to form the osteoclast functional antigen (vitronectin receptor). Integrin alpha V is found in osteoclasts, placenta, melanoma cell lines and some epithelial cell lines. Expression of integrin alpha V increases with melanoma progression. 23C6 may be useful for bone resorption modulation, osteoclast identification, receptor purification, malignant melanoma identification and treatment.
Host Mouse
Immunogen A cell suspension containing osteoclasts from osteoclastomas.
Subclass IgG1
Positive Control Tonsil
Molecular Weight (kDa) 125/124, 150
Myeloma Used P3X63Ag8.653
Recommended Growing Conditions DMEM + 5% FCS
Strain Balb/c
Notes 125/124 kDa (reduced), 150kDa (non-reduced)
Research Area Adhesion, Cancer, Cardiovascular

References: 10 entries

MMP-2 alters VEGF expression via alphaVbeta3 integrin-mediated PI3K/AKT signaling in A549 lung cancer cells.

Europe PMC ID: 20027628

Chetty et al. 2010. Int J Cancer. 127(5):1081-95. PMID: 20027628.

IP

Martino et al. 2009. Biomaterials. 30(6):1089-97. PMID: 19027948.

Controlling integrin specificity and stem cell differentiation in 2D and 3D environments through regulation of fibronectin domain stability.

Europe PMC ID: 19027948

Zhou et al. 2006. J Exp Med. 203(4):1067-80. PMID: 16606672.

Regulation of osteoclast function and bone mass by RAGE.

Europe PMC ID: 16606672

Marshall et al. 1995. J Cell Sci. 108 ( Pt 3):1227-38. PMID: 7542669.

Alpha v beta 1 is a receptor for vitronectin and fibrinogen, and acts with alpha 5 beta 1 to mediate spreading on fibronectin.

Europe PMC ID: 7542669

Horton et al. 1985. Cancer Res. 45(11 Pt 2):5663-9. PMID: 4053038.

Monoclonal antibodies to osteoclastomas (giant cell bone tumors): definition of osteoclast-specific cellular antigens.

Europe PMC ID: 4053038


Add a reference

References: 10 entries

MMP-2 alters VEGF expression via alphaVbeta3 integrin-mediated PI3K/AKT signaling in A549 lung cancer cells.

Europe PMC ID: 20027628

Chetty et al. 2010. Int J Cancer. 127(5):1081-95. PMID: 20027628.

IP

Martino et al. 2009. Biomaterials. 30(6):1089-97. PMID: 19027948.

Controlling integrin specificity and stem cell differentiation in 2D and 3D environments through regulation of fibronectin domain stability.

Europe PMC ID: 19027948

Zhou et al. 2006. J Exp Med. 203(4):1067-80. PMID: 16606672.

Regulation of osteoclast function and bone mass by RAGE.

Europe PMC ID: 16606672

Marshall et al. 1995. J Cell Sci. 108 ( Pt 3):1227-38. PMID: 7542669.

Alpha v beta 1 is a receptor for vitronectin and fibrinogen, and acts with alpha 5 beta 1 to mediate spreading on fibronectin.

Europe PMC ID: 7542669

Horton et al. 1985. Cancer Res. 45(11 Pt 2):5663-9. PMID: 4053038.

Monoclonal antibodies to osteoclastomas (giant cell bone tumors): definition of osteoclast-specific cellular antigens.

Europe PMC ID: 4053038


Add a reference

References: 10 entries

MMP-2 alters VEGF expression via alphaVbeta3 integrin-mediated PI3K/AKT signaling in A549 lung cancer cells.

Chetty et al. 2010. Int J Cancer. 127(5):1081-95. PMID: 20027628.

IP

Martino et al. 2009. Biomaterials. 30(6):1089-97. PMID: 19027948.

Controlling integrin specificity and stem cell differentiation in 2D and 3D environments through regulation of fibronectin domain stability.

Zhou et al. 2006. J Exp Med. 203(4):1067-80. PMID: 16606672.

Regulation of osteoclast function and bone mass by RAGE.

Marshall et al. 1995. J Cell Sci. 108 ( Pt 3):1227-38. PMID: 7542669.

Alpha v beta 1 is a receptor for vitronectin and fibrinogen, and acts with alpha 5 beta 1 to mediate spreading on fibronectin.

Horton et al. 1985. Cancer Res. 45(11 Pt 2):5663-9. PMID: 4053038.

Monoclonal antibodies to osteoclastomas (giant cell bone tumors): definition of osteoclast-specific cellular antigens.


Add a reference


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