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|Applications||FACS IHC IP Fn|
|Antigen/Gene or Protein Targets||Integrin alpha V ß3 (CD51/61; Osteoclast Functional Antigen)|
|Relevance||Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin alpha V associates with integrin beta3 to form the osteoclast functional antigen (vitronectin receptor). Integrin alpha V is found in osteoclasts, placenta, melanoma cell lines and some epithelial cell lines. Expression of integrin alpha V increases with melanoma progression. 23C6 may be useful for bone resorption modulation, osteoclast identification, receptor purification, malignant melanoma identification and treatment.|
|Immunogen||A cell suspension containing osteoclasts from osteoclastomas.|
|Molecular Weight (kDa)||125/124, 150|
|Recommended Growing Conditions||DMEM + 5% FCS|
|Notes||125/124 kDa (reduced), 150kDa (non-reduced)|
|Research Area||Adhesion, Cancer, Cardiovascular|
References: 5 entries
Chetty et al. 2010. Int J Cancer. 127(5):1081-95. PMID: 20027628.
Martino et al. 2009. Biomaterials. 30(6):1089-97. PMID: 19027948.
Zhou et al. 2006. J Exp Med. 203(4):1067-80. PMID: 16606672.
Marshall et al. 1995. J Cell Sci. 108 ( Pt 3):1227-38. PMID: 7542669.
Horton et al. 1985. Cancer Res. 45(11 Pt 2):5663-9. PMID: 4053038.
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