Cancer Research Technology
Log in Register
Menu

Info

Catalogue Number 151026
Applications FACS IHC IF IP Fn
Antigen/Gene or Protein Targets Fc-gamma receptor 1 (FCGR1, CD64)
Synonyms Fc Fragment Of IgG Receptor Ia; Fc Gamma Receptor Ia; Fc-Gamma RIA; IGFR1; FCRI; Fc Gamma Receptor; CD64 Antigen; FCGR1; CD64; FCG1
Reactivity Human
Relevance Fc-gamma receptor 1 (CD64) is an IgG receptor expressed by monocytes and myeloid cell lines. It is a marker of iflammation. It is involved in cancer and many chronic diseases (arthritis, multiple sclerosis, diabetic ulcers), but also in antibody-dependent cell-mediated cytotoxicity (ADCC), sepsis, automimmune disorders and periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome. The 10.1 antibody blocks the Ig binding to FcR1 receptor.
Host Mouse
Immunogen Rheumatoid synovial fluid cells and fibronectin purified human monocytes.
Subclass IgG1
Positive Control Myeloid cell lines U937 and HL60
Molecular Weight (kDa) 71
Myeloma Used Sp2/0-Ag14
Recommended Growing Conditions DMEM + 5% FCS
Strain Balb/c
Research Area Cancer, Immunology

References: 28 entries

Sips et al. 2016. Mucosal Immunol. :. PMID: 26883728.

Fc receptor-mediated phagocytosis in tissues as a potent mechanism for preventive and therapeutic HIV vaccine strategies.

Europe PMC ID: 26883728

Macrophage response to oncolytic paramyxoviruses potentiates virus-mediated tumor cell killing.

Europe PMC ID: 26763072

Tan et al. 2016. Eur J Immunol. :. PMID: 26763072.

FACS

Vascular Health Profile predicts cardiovascular outcomes in patients with diabetes.

Europe PMC ID: 26566003

Hanihara et al. 2015. J Neurosurg. :1-8. PMID: 26636389.

Synergistic antitumor effect with indoleamine 2,3-dioxygenase inhibition and temozolomide in a murine glioma model.

Europe PMC ID: 26636389

Rogers et al. 2015. Cytometry B Clin Cytom. :. PMID: 26566003.

Tutt et al. 2015. J Immunol. :. PMID: 26512139.

FACS

Development and Characterization of Monoclonal Antibodies Specific for Mouse and Human Fcγ Receptors.

Europe PMC ID: 26512139

Pathways Responsible for Human Autoantibody and Therapeutic Intravenous IgG Activity in Humanized Mice.

Europe PMC ID: 26456831

Schwab et al. 2015. Cell Rep. :. PMID: 26456831.

Sousa et al. 2015. Breast Cancer Res. 17(1):101. PMID: 26243145.

FACS

Human breast cancer cells educate macrophages toward the M2 activation status.

Europe PMC ID: 26243145

Conrad et al. 2015. Arthritis Res Ther. 17:179. PMID: 26178906.

FACS

In vivo pre-activation of monocytes in patients with axial spondyloarthritis.

Europe PMC ID: 26178906

Up-regulation of CD64-expressing monocytes with impaired FcγR function reflects disease activity in polyarticular psoriatic arthritis.

Europe PMC ID: 26084203

Matt et al. 2015. Scand J Rheumatol. :1-10. PMID: 26084203.

Pilling et al. 2015. PLoS One. 10(3):e0119709. PMID: 25774777.

Sutherland et al. 2015. Curr Protoc Cytom. 72:6.37.1-6.37.29. PMID: 25827482.

High-Sensitivity Detection of PNH Red Blood Cells, Red Cell Precursors, and White Blood Cells.

Europe PMC ID: 25827482

The long pentraxin PTX3 promotes fibrocyte differentiation.

Europe PMC ID: 25774777

Schleinitz et al. 2008. Arthritis Rheum. 58(10):3216-23. PMID: 18821690.

Expression of the CD85j (leukocyte Ig-like receptor 1, Ig-like transcript 2) receptor for class I major histocompatibility complex molecules in idiopathic inflammatory myopathies.

Europe PMC ID: 18821690

Jayaram et al. 1989. Clin Exp Immunol. 75(3):414-20. PMID: 2495203.

The Fc receptor, FcRI, and other activation molecules on human mononuclear phagocytes after treatment with interferon-gamma.

Europe PMC ID: 2495203

Dougherty et al. 1987. Eur J Immunol. 17(10):1453-9. PMID: 3500057.

The human mononuclear phagocyte high-affinity Fc receptor, FcRI, defined by a monoclonal antibody, 10.1.

Europe PMC ID: 3500057


Add a reference

References: 28 entries

Sips et al. 2016. Mucosal Immunol. :. PMID: 26883728.

Fc receptor-mediated phagocytosis in tissues as a potent mechanism for preventive and therapeutic HIV vaccine strategies.

Europe PMC ID: 26883728

Macrophage response to oncolytic paramyxoviruses potentiates virus-mediated tumor cell killing.

Europe PMC ID: 26763072

Tan et al. 2016. Eur J Immunol. :. PMID: 26763072.

FACS

Vascular Health Profile predicts cardiovascular outcomes in patients with diabetes.

Europe PMC ID: 26566003

Hanihara et al. 2015. J Neurosurg. :1-8. PMID: 26636389.

Synergistic antitumor effect with indoleamine 2,3-dioxygenase inhibition and temozolomide in a murine glioma model.

Europe PMC ID: 26636389

Rogers et al. 2015. Cytometry B Clin Cytom. :. PMID: 26566003.

Tutt et al. 2015. J Immunol. :. PMID: 26512139.

FACS

Development and Characterization of Monoclonal Antibodies Specific for Mouse and Human Fcγ Receptors.

Europe PMC ID: 26512139

Pathways Responsible for Human Autoantibody and Therapeutic Intravenous IgG Activity in Humanized Mice.

Europe PMC ID: 26456831

Schwab et al. 2015. Cell Rep. :. PMID: 26456831.

Sousa et al. 2015. Breast Cancer Res. 17(1):101. PMID: 26243145.

FACS

Human breast cancer cells educate macrophages toward the M2 activation status.

Europe PMC ID: 26243145

Conrad et al. 2015. Arthritis Res Ther. 17:179. PMID: 26178906.

FACS

In vivo pre-activation of monocytes in patients with axial spondyloarthritis.

Europe PMC ID: 26178906

Up-regulation of CD64-expressing monocytes with impaired FcγR function reflects disease activity in polyarticular psoriatic arthritis.

Europe PMC ID: 26084203

Matt et al. 2015. Scand J Rheumatol. :1-10. PMID: 26084203.

Pilling et al. 2015. PLoS One. 10(3):e0119709. PMID: 25774777.

Sutherland et al. 2015. Curr Protoc Cytom. 72:6.37.1-6.37.29. PMID: 25827482.

High-Sensitivity Detection of PNH Red Blood Cells, Red Cell Precursors, and White Blood Cells.

Europe PMC ID: 25827482

The long pentraxin PTX3 promotes fibrocyte differentiation.

Europe PMC ID: 25774777

Schleinitz et al. 2008. Arthritis Rheum. 58(10):3216-23. PMID: 18821690.

Expression of the CD85j (leukocyte Ig-like receptor 1, Ig-like transcript 2) receptor for class I major histocompatibility complex molecules in idiopathic inflammatory myopathies.

Europe PMC ID: 18821690

Jayaram et al. 1989. Clin Exp Immunol. 75(3):414-20. PMID: 2495203.

The Fc receptor, FcRI, and other activation molecules on human mononuclear phagocytes after treatment with interferon-gamma.

Europe PMC ID: 2495203

Dougherty et al. 1987. Eur J Immunol. 17(10):1453-9. PMID: 3500057.

The human mononuclear phagocyte high-affinity Fc receptor, FcRI, defined by a monoclonal antibody, 10.1.

Europe PMC ID: 3500057


Add a reference

References: 28 entries

Sips et al. 2016. Mucosal Immunol. :. PMID: 26883728.

Fc receptor-mediated phagocytosis in tissues as a potent mechanism for preventive and therapeutic HIV vaccine strategies.

Macrophage response to oncolytic paramyxoviruses potentiates virus-mediated tumor cell killing.

Tan et al. 2016. Eur J Immunol. :. PMID: 26763072.

FACS

Vascular Health Profile predicts cardiovascular outcomes in patients with diabetes.

Hanihara et al. 2015. J Neurosurg. :1-8. PMID: 26636389.

Synergistic antitumor effect with indoleamine 2,3-dioxygenase inhibition and temozolomide in a murine glioma model.

Rogers et al. 2015. Cytometry B Clin Cytom. :. PMID: 26566003.

Tutt et al. 2015. J Immunol. :. PMID: 26512139.

FACS

Development and Characterization of Monoclonal Antibodies Specific for Mouse and Human Fcγ Receptors.

Pathways Responsible for Human Autoantibody and Therapeutic Intravenous IgG Activity in Humanized Mice.

Schwab et al. 2015. Cell Rep. :. PMID: 26456831.

Sousa et al. 2015. Breast Cancer Res. 17(1):101. PMID: 26243145.

FACS

Human breast cancer cells educate macrophages toward the M2 activation status.

Conrad et al. 2015. Arthritis Res Ther. 17:179. PMID: 26178906.

FACS

In vivo pre-activation of monocytes in patients with axial spondyloarthritis.

Up-regulation of CD64-expressing monocytes with impaired FcγR function reflects disease activity in polyarticular psoriatic arthritis.

Matt et al. 2015. Scand J Rheumatol. :1-10. PMID: 26084203.

Pilling et al. 2015. PLoS One. 10(3):e0119709. PMID: 25774777.

Sutherland et al. 2015. Curr Protoc Cytom. 72:6.37.1-6.37.29. PMID: 25827482.

High-Sensitivity Detection of PNH Red Blood Cells, Red Cell Precursors, and White Blood Cells.

The long pentraxin PTX3 promotes fibrocyte differentiation.

Schleinitz et al. 2008. Arthritis Rheum. 58(10):3216-23. PMID: 18821690.

Expression of the CD85j (leukocyte Ig-like receptor 1, Ig-like transcript 2) receptor for class I major histocompatibility complex molecules in idiopathic inflammatory myopathies.

Jayaram et al. 1989. Clin Exp Immunol. 75(3):414-20. PMID: 2495203.

The Fc receptor, FcRI, and other activation molecules on human mononuclear phagocytes after treatment with interferon-gamma.

Dougherty et al. 1987. Eur J Immunol. 17(10):1453-9. PMID: 3500057.

The human mononuclear phagocyte high-affinity Fc receptor, FcRI, defined by a monoclonal antibody, 10.1.


Add a reference


This reagent does not have any reviews at the moment.