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Anti-IL12 [1-1A4]

Info

Catalogue Number 151022
Applications ELISA IHC RIA WB
Antigen/Gene or Protein Targets Interleukin-12 (IL12) p40 subunit
Synonyms Interleukin 12; Cytotoxic Lymphocyte Maturation Factor 40 KDa Subunit; NK Cell Stimulatory Factor Chain; Interleukin-12 Beta Chain; IL-12 Subunit P40; CLMF P40; NKSF2; Natural Killer Cell Stimulatory Factor; IL12; Subunit P40; Interleukin 12; CLMF2; IMD29; NKSF; P40
Reactivity Human
Relevance IL-12 is a heterodimeric cytokine comprised of p35 and p40 subunits. IL-12 plays a central role in cell-mediated immunity, promoting the differentiation of CD4+ T cells to the Th1 subset and of CD8+ T cells into mature cytotoxic T lymphocytes (CTLs). IL-12 is a potent stimulator of Natural Killer cells. IL-12 therapy has been suggested as a method of enhancing cytocidal anti-tumour immune responses.
Host Mouse
Immunogen Recombinant human IL-12 produced in Baculovirus.
Subclass IgG1
Myeloma Used Sp2/0-Ag14
Recommended Growing Conditions DMEM + 5% FCS.
Research Area Immunology

References: 3 entries

Nagashima et al. 2008. Anticancer Res. 28(2B):1277-83. PMID: 18505066.

Nakayama et al. 2004. Anticancer Res. 24(5C):3289-94. PMID: 15515423.

Carter et al. 1997. Hybridoma. 16(4):363-9. PMID: 9309427.


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