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Anti-CyclinB1 [V152]


Catalogue Number 151021
Applications FACS IHC WB
Antigen/Gene or Protein Targets Cyclin B1
Synonyms CCNB1; Cyclin B1; G2/Mitotic-Specific Cyclin B1; CCNB
Reactivity Mammalian
Relevance Cyclins bind to and regulate the activity of the Cyclin Dependent Protein Kinases (CDKs). Cyclin B1 is a marker of cell proliferation and a key component of the cell cycle progression machinery. Cyclin B1 may prove to be a prognostic marker in neoplasia.
Host Mouse
Immunogen His tagged Hamster Cyclin B1 expressed in bacteria, harvested from inclusion bodies, extracted with 6M guanidine HC1 and purified on Nickel beads.
Subclass IgG1
Myeloma Used Sp2/0-Ag14
Recommended Growing Conditions DMEM + 5% FCS
Notes Recommended for the detection of cyclin B1 in formalin fixed tissues.
Research Area Cancer, Cell Cycle, Epigenetics & Nuclear Signalling

References: 4 entries

Gurden et al. 2010. J Cell Sci. 123(Pt 3):321-30. PMID: 20053638.

Geley et al. 2001. J Cell Biol. 153(1):137-48. PMID: 11285280.

Minemoto et al. 2001. Exp Cell Res. 262(1):37-48. PMID: 11120603.

Brandeis et al. 1998. Proc Natl Acad Sci U S A. 95(8):4344-9. PMID: 9539739.

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