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Anti-CyclinA [E72.1]


Catalogue Number 151016
Applications IHC IF IP WB
Antigen/Gene or Protein Targets Cyclin A
Synonyms CCNA1; Cyclin A1; Testicular Tissue Protein Li 34; CT146
Reactivity Bovine
Relevance Cyclins bind to and regulate the activity of the Cyclin Dependent Protein Kinases (CDKs). Cyclin A is involved in the regulation of the cell cycle and is essential for progression through S phase. Cyclin A protein is absent in cells prior to S-phase, during which its levels increase and peak. Cyclin A is a marker for actively proliferating cells and for cells in S phase.
Host Mouse
Immunogen Bovine Cyclin A
Subclass IgG1
Myeloma Used Sp2/0-Ag14
Recommended Growing Conditions DMEM + 5% FCS
Notes E72.1 has been used to co-immunoprecipitates CIP-1 in active trimeric complexes of cyclinA cdk-CIP-1.
E72.1 is not recommended for use on parrafin embedded specimens.
Research Area Cancer, Cell Cycle, Epigenetics & Nuclear Signalling

References: 2 entries

Garner et al. 2002. Oncogene. 21(53):8089-104. PMID: 12444545.

Bashir et al. 2000. Proc Natl Acad Sci U S A. 97(10):5522-7. PMID: 10792046.

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