"Super-active" Interleukin-33 (IL-33) fragment Peptide
Invented by Jean-Philippe Girard
Invented at University of Toulouse
- Datasheet
- References (1)
- Inventor Info
Info
| Catalogue Number | 159673 |
| Source | Plasmid |
| Synonyms | Interleukin-33, IL-33, C9orf26, IL1F11, NFHEV |
| Relevance | Interleukin 33 is a member of the IL-1 family that potently drives production of T helper-2 (Th2)-associated cytokines. IL-33 is expressed by a wide variety of cell types, including fibroblasts, mast cells, dendritic cells, macrophages, osteoblasts, endothelial cells, and epithelial cells. Extracellular IL-33 activates a growing number of target cells, including group 2 innate lymphoid cells, mast cells and regulatory T cells. It can be used in life science research to induce inflammation in vivo and in vitro. IL-33 has also been shown to be effective in reversing Alzheimer-like symptoms in APP/PS1 mice, by reversing the buildup and preventing the new formation of amyloid plaques. |
| Antigen/Gene or Protein Targets | Interleukin-33 |
| Notes |
This fragment of IL-33 has been shown to be more strongly activate inflammatory responses in cells than the full-length protein, making it a good tool for inflammatory research. Patent FR2972006A1: https://worldwide.espacenet.com/patent/search/family/044533285/publication/FR2972006A1?q=FR2972006A1 |
| Research Area | Immunology |
References: 1 entry
References: 1 entry
Inventor Information
Inventors
|
Jean-Philippe Girard |
