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Tamoxifen-resistant MCF-7 Breast Cancer cell line

Info

Catalogue Number 156418
Antigen/Gene or Protein Targets tamoxifen resistant breast cancer
Disease Keywords Breast Cancer
Model Cancer Model
Relevance MCF-7 cells serve as a prototypic model system for human breast cancer and their response to secretive endocrine response modifiers (SERM) therapy. MCF-7 cells, upon long term exposure to tamoxifen, acquire tam-resistance and continue to grow in the presence of tamoxifen. This provides a cell-based model , both in vitro and in vivo, for tam-resistant breast cancer, allows the testing of alternate therapies to tam-resistant breast cancer, or the high-throughput testing of drugs that might synergize with hormone based therapies.
Research Area Cancer, Drug Discovery & Development
Cellosaurus ID CVCL_EG55

References

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References: 1 entry

Wu et al. 2015. Mol Cell Proteomics. 14(11):2887-900. PMID: 26330541.


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References: 1 entry

Wu et al. 2015. Mol Cell Proteomics. 14(11):2887-900. PMID: 26330541.


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