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Catalogue Number
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154731 |
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Applications
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EM
FACS
IHC
IF
IP
WB
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Antigen/Gene or Protein Targets
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cErbB2/HER-2
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|
Synonyms
|
NEU
|
|
Reactivity
|
Human
|
|
Relevance
|
HER2 is a member of the human epidermal growth factor receptor (HER/EGFR/ERBB) family. Amplification or over-expression of this oncogene has been shown to play an important role in the development and progression of certain aggressive types of breast cancer. In recent years the protein has become an important biomarker and target of therapy for approximately 30% of breast cancer patients
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|
Host
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Mouse
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Immunogen
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protein.
|
|
Subclass
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IgG1
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|
Molecular Weight (kDa)
|
185
|
|
Recommended Growing Conditions
|
IMDM + 10% FBS ulta low IgG, 37 ⁰C 5% CO2
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|
Notes
|
Reacts with a cell surface epitope of c-Erb2/c-Neu but does not cross react with EGF. Ductal carcinomas in situ displaying large cell, comedo growth type, where stained while none of 16 ductal carcinomas in situ of small cell, papillary, or cribiform growth type were stained by this mab.
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|
Research Area
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Cancer, Cell Signaling & Signal Transduction
|
