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Anti-cErbB2/HER2 [9G6] monoclonal Antibody
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Catalogue Number 154731
Applications EM FACS IHC IF IP WB
Antigen/Gene or Protein Targets cErbB2/HER-2
Synonyms NEU
Reactivity Human
Relevance HER2 is a member of the human epidermal growth factor receptor (HER/EGFR/ERBB) family. Amplification or over-expression of this oncogene has been shown to play an important role in the development and progression of certain aggressive types of breast cancer. In recent years the protein has become an important biomarker and target of therapy for approximately 30% of breast cancer patients
Host Mouse
Immunogen protein.
Subclass IgG1
Molecular Weight (kDa) 185
Recommended Growing Conditions IMDM + 10% FBS ulta low IgG, 37 ⁰C 5% CO2
Notes Reacts with a cell surface epitope of c-Erb2/c-Neu but does not cross react with EGF. Ductal carcinomas in situ displaying large cell, comedo growth type, where stained while none of 16 ductal carcinomas in situ of small cell, papillary, or cribiform growth type were stained by this mab.
Research Area Cancer, Cell Signaling & Signal Transduction

References

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References: 1 entry

van de Vijver et al. 1988. N Engl J Med. 319(19):1239-45. PMID: 2903446.


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References: 1 entry

van de Vijver et al. 1988. N Engl J Med. 319(19):1239-45. PMID: 2903446.


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