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Anti-LIMD1 [3F2/C6]

Invented by Dr Tyson Sharp at Barts Cancer Institute

Info

Catalogue Number 154092
Applications ELISA IHC IF IP WB
Antigen/Gene or Protein Targets LIM domains containing 1
Synonyms LIM domain-containing protein 1
Reactivity Human
Relevance LIMD1 (LIM domain-containing protein 1) is part of the zyxin/ajuba family of proteins and is a ubiquitously expressed tumour suppressor containing three LIM zinc-binding domains. LIMD1 may be involved in cell anchoring via focal adhesions and in the cell cycle, particularly during mitosis. Limd1 interacts with the proteins SQSTM1, Rb, p62 and TRAF6. Limd1 was first identified when the deletion of its gene was noted in some cervical cancers, and it has since been noted to be downregulated in lung and breast cancers.
Host Mouse
Immunogen Recombinant LIMD4
Positive Control H1299 cell lysate
Subclass IgG1
Myeloma Used P3X63Ag8.653
Strain Balb/c
Research Area Cancer

References

There are 8 reference entries for this reagent.

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References: 8 entries

Foxler et al. 2018. EMBO Mol Med. 10(8):. PMID: 29930174.

A HIF-LIMD1 negative feedback mechanism mitigates the pro-tumorigenic effects of hypoxia.

Europe PMC ID: 29930174

Chakraborty et al. 2018. Biochem J. 475(10):1793-1806. PMID: 29654110.

Deregulation of LIMD1-VHL-HIF-1α-VEGF pathway is associated with different stages of cervical cancer.

Europe PMC ID: 29654110

Foxler et al. 2012. Nat Cell Biol. 14(2):201-8. PMID: 22286099.

The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity.

Europe PMC ID: 22286099

Sharp et al. 2008. Proc Natl Acad Sci U S A. 105(50):19932-7. PMID: 19060205.

The chromosome 3p21.3-encoded gene, LIMD1, is a critical tumor suppressor involved in human lung cancer development.

Europe PMC ID: 19060205


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References: 8 entries

Foxler et al. 2018. EMBO Mol Med. 10(8):. PMID: 29930174.

A HIF-LIMD1 negative feedback mechanism mitigates the pro-tumorigenic effects of hypoxia.

Chakraborty et al. 2018. Biochem J. 475(10):1793-1806. PMID: 29654110.

Deregulation of LIMD1-VHL-HIF-1α-VEGF pathway is associated with different stages of cervical cancer.

Foxler et al. 2012. Nat Cell Biol. 14(2):201-8. PMID: 22286099.

The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity.

Sharp et al. 2008. Proc Natl Acad Sci U S A. 105(50):19932-7. PMID: 19060205.

The chromosome 3p21.3-encoded gene, LIMD1, is a critical tumor suppressor involved in human lung cancer development.


Add a reference