Anti-Mycobacterial 30-kDa [A3c12]
Invented by Professor Pranab K Das
Invented at
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- References (4)
- Inventor Info
Info
| Catalogue Number | 154073 |
| Applications | ELISA IHC WB |
| Antigen/Gene or Protein Targets | Mycobacterial 30-kDa |
| Reactivity | Mycobacterium bovis |
| Relevance | Proteins of the antigen 85 complex in the 30-kDa region secreted by live mycobacteria are important in the immune response against mycobacterial infections and play an important biological role in the host-parasite interaction. This antibody recognises antigens 85A (MPT44) and 85B (MPT59). This antibody stains the paucibacillary borderline and tuberculoid leprosy lesions. |
| Host | Mouse |
| Immunogen | 30-kDa antigen isolated from M.tuberculosis (RIVM-strain 7114) |
| Positive Control | M.tuberculosis |
| Subclass | IgG2a |
| Myeloma Used | P3X63Ag8.653 |
| Recommended Growing Conditions | RPMI 1640 |
| Strain | Balb/c |
| Notes | Reacts with M.bovis BCG, M.tuberculosis complex and M.leprae. Does not react with E.coli. Epitope of the secreted antigen 85 complex mapped to amino acid residues 55-266 |
| Research Area | Bacteriology, Immunology, Microbiology |
References: 4 entries
Rambukkana et al. 1993. Infect Immun. 61(5):1835-45. PMID: 7682995.
The mycobacterial secreted antigen 85 complex possesses epitopes that are differentially expressed in human leprosy lesions and Mycobacterium leprae-infected armadillo tissues.
Europe PMC ID: 7682995
Rambukkana et al. 1992. Infect Immun. 60(12):5172-81. PMID: 1280626.
Heterogeneity of monoclonal antibody-reactive epitopes on mycobacterial 30-kilodalton-region proteins and the secreted antigen 85 complex and demonstration of antigen 85B on the Mycobacterium leprae cell wall surface.
Europe PMC ID: 1280626
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References: 4 entries
Rambukkana et al. 1993. Infect Immun. 61(5):1835-45. PMID: 7682995.
The mycobacterial secreted antigen 85 complex possesses epitopes that are differentially expressed in human leprosy lesions and Mycobacterium leprae-infected armadillo tissues.
Rambukkana et al. 1992. Infect Immun. 60(12):5172-81. PMID: 1280626.
Heterogeneity of monoclonal antibody-reactive epitopes on mycobacterial 30-kilodalton-region proteins and the secreted antigen 85 complex and demonstration of antigen 85B on the Mycobacterium leprae cell wall surface.
Add a reference
