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Anti-phospho Sam68, Ser113/117, Polyclonal Antibody

Info

Catalogue Number 153988
Applications IHC WB
Antigen/Gene or Protein Targets Sam68 (Src-associated during mitosis, 68 kDa) 
Synonyms KH domain-containing, RNA-binding, signal transduction-associated protein 1, GAP-associated tyrosine phosphoprotein p62, Src-associated in mitosis 68 kDa protein, p21 Ras GTPase-activating protein-associated p62, p68
Reactivity Human, Mouse and Rat
Relevance Sam68 (KHDRBS1 also known as KH domain-containing, RNA-binding, signal transduction-associated protein 1) is a RNA binding protein that binds to U(U/A)AA direct repeats to regulate RNA splicing, transcription, RNA metabolism, signal transduction, the cell cycle and apoptosis. Post-translational modifications on Sam68 is what allows it to regulate many different cellular process. For instance, when Sam68 is phosphorylated, on serine 113 and 117, it forms nuclear factor-kappaB (NF-κB) complexes and binds to promoters of genomic targets important for human lymphocyte activation.
Host Rabbit
Immunogen Synthetic peptide (NH2-CAEKD(Sp)LDP(Sp)FTH-COOH)
Molecular Weight (kDa) 68 kDa
Research Area Apoptosis and Programmed Cell Death, Cell Cycle, Cell Signaling & Signal Transduction, Gene Expression

References

There are 2 reference entries for this reagent.

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References: 2 entries

Fu et al. 2013. Nat Commun. 4:1909. PMID: 23715268.

Sam68 modulates the promoter specificity of NF-κB and mediates expression of CD25 in activated T cells.

Europe PMC ID: 23715268


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References: 2 entries

Fu et al. 2013. Nat Commun. 4:1909. PMID: 23715268.

Sam68 modulates the promoter specificity of NF-κB and mediates expression of CD25 in activated T cells.


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