Cancer Research Technology
Log in Register
Menu

Oct1/2 Knock Out Mouse

Info

Catalogue Number 153874
Antigen/Gene or Protein Targets Oct1 and Oct2
Synonyms SLC22A1/2, Solute Carrier Family 22 Member 1/2, Organic Cation Transporter 1/2
Model Knock-Out
Relevance Oct1/2 are polyspecific organic cation transporters in the liver, kidney, intestine, and other organs. They are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins
Production Details The model was created through sequential targeting of the Slc22a1 and Slc22a2 genes in 129/Ola-derived E14 ES cells and injecting the targeted cells into C57BL/6 blastocysts. Resultant chimeras were backcrossed to FVB/N for seven generations
Breeding Information The colony is maintained by mating doubly homozygous mic
Conditional No
Mouse Genetic Background/Cross History FVB Background
Zygosity Homozygous
Research Area Cancer, Cell Signaling & Signal Transduction, Drug Discovery & Development
Notes Useful for studies of drug transport in the liver, intestine and kidneys. OCT1 and OCT2 determine renal secretion of small organic cations.
The Oct1/2 mouse was developed in the laboratory of Alfred Schinkel of the Netherlands Cancer Institute

References

There are 4 reference entries for this reagent.

View All References

References: 4 entries

Jonker et al. 2003. Mol Cell Biol. 23(21):7902-8. PMID: 14560032.

Deficiency in the organic cation transporters 1 and 2 (Oct1/Oct2 [Slc22a1/Slc22a2]) in mice abolishes renal secretion of organic cations.

Europe PMC ID: 14560032

Jonker et al. 2001. Mol Cell Biol. 21(16):5471-7. PMID: 11463829.

Reduced hepatic uptake and intestinal excretion of organic cations in mice with a targeted disruption of the organic cation transporter 1 (Oct1 [Slc22a1]) gene.

Europe PMC ID: 11463829


Add a reference

References: 4 entries

Jonker et al. 2003. Mol Cell Biol. 23(21):7902-8. PMID: 14560032.

Deficiency in the organic cation transporters 1 and 2 (Oct1/Oct2 [Slc22a1/Slc22a2]) in mice abolishes renal secretion of organic cations.

Jonker et al. 2001. Mol Cell Biol. 21(16):5471-7. PMID: 11463829.

Reduced hepatic uptake and intestinal excretion of organic cations in mice with a targeted disruption of the organic cation transporter 1 (Oct1 [Slc22a1]) gene.


Add a reference

Inventor Information

No inventors are currently linked to this reagent.

Add an inventor